上臂中部周长用于识别儿童和青少年超重和肥胖的诊断性能：系统评价和荟萃分析的方案。

Diagnostic performance of mid-upper arm circumference to identify overweight and obesity in children and adolescents: a protocol for a systematic review and meta-analysis.

机构信息

Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia

Department of Public Health, Mizan-Tepi University, Mizan, Ethiopia.

出版信息

BMJ Open. 2021 Mar 31;11(3):e044624. doi: 10.1136/bmjopen-2020-044624.

DOI:10.1136/bmjopen-2020-044624

PMID:33789852

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016083/

Abstract

INTRODUCTION

Mid-upper arm circumference (MUAC) has been suggested as an alternative screening tool to identify overweight and obesity in children and adolescents. Several studies have examined the diagnostic performance of MUAC to identify overweight and obesity in children and adolescents. However, the existing literature shows a considerable variability in measures of diagnostic performance and hence makes it difficult to direct clinical and public health practice. Therefore, this systematic review and meta-analysis aimed to synthesise evidence on the performance of MUAC to identify overweight and obesity in children and adolescents.

METHODS AND ANALYSIS

A systematic search of databases including PubMed, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews, Cochrane CENTRAL, Web of Science, CINAHL and PsycINFO will be conducted. The search will cover all studies until 1 April 2021. Grey literature will also be retrieved from Google Scholar. Titles and abstracts will be screened by two independent reviewers. The Quality Assessment of Diagnostic Accuracy Studies 2 tool will be used to assess the risk of bias and clinical applicability of each study. To assess possible publication bias, we will use Deeks' funnel plot. We will investigate the sources of heterogeneity by visual inspection of the paired forest plots and summary receiver operating characteristic plots. The pooled summary statistics for the area under the curve, sensitivities, specificities, likelihood ratios and diagnostic ORs with 95% CI will be reported.

ETHICS AND DISSEMINATION

The underlying study is based on published articles thus does not require ethical approval. The findings of the systematic review and meta-analysis will be published in a peer-reviewed journal and disseminated in different scientific conferences and seminars.

PROSPERO REGISTRATION NUMBER

CRD42020183148.

摘要

简介

中上臂围（MUAC）已被建议作为一种替代筛查工具，用于识别儿童和青少年超重和肥胖。多项研究已经检验了 MUAC 对儿童和青少年超重和肥胖的诊断性能。然而，现有文献表明，其诊断性能的衡量标准存在相当大的差异，因此难以指导临床和公共卫生实践。因此，本系统评价和荟萃分析旨在综合 MUAC 识别儿童和青少年超重和肥胖的证据。

方法和分析

我们将对包括 PubMed、EMBASE、SCOPUS、Cochrane 系统评价数据库、Cochrane 中心、Web of Science、CINAHL 和 PsycINFO 在内的数据库进行系统检索。检索将涵盖截至 2021 年 4 月 1 日的所有研究。还将从 Google Scholar 中检索灰色文献。两名独立评审员将筛选标题和摘要。将使用诊断准确性研究质量评估 2 工具评估每项研究的偏倚风险和临床适用性。为了评估可能存在的发表偏倚，我们将使用 Deeks 漏斗图。我们将通过视觉检查配对森林图和综合受试者工作特征图来调查异质性的来源。将报告汇总的曲线下面积、敏感度、特异度、似然比和诊断 OR 的汇总统计数据，以及 95%CI。