Katsura Yoshiteru, Takeda Yutaka, Ohmura Yoshiaki, Sakamoto Takuya, Shinke Go, Katsuyama Shinsuke, Kawai Kenji, Kitahara Tomohiro, Hiraki Masayuki, Murakami Kohei, Kagawa Yoshinori, Masuzawa Toru, Takeno Atsushi, Hata Taishi, Murata Kohei
Dept. of Surgery, Kansai Rosai Hospital.
Gan To Kagaku Ryoho. 2021 Mar;48(3):394-396.
Pancreatic neuroendocrine tumor(p-NET)is a relatively rare disease, and treatment is multidisciplinary with resection, local therapy, radiotherapy, and chemotherapy. We report on a case in which long-term survival was achieved by multidisciplinary treatment. The case is a 47-year-old male. He was referred to our hospital because of the diagnosis of pancreatic tail tumor and underwent distal pancreatectomy in May 2008. And he was diagnosed as p-NET G1 by the pathological results. After 3 TACE treatments and 1 partial liver resection for recurrent liver metastasis, multiple liver metastases and lymph node metastases were found in August 2014. As a result of the everolimus treatment, the determination of efficacy to lymph nodes was CR and liver lesions were CR with the addition of TACE treatment. In July 2017, he had multiple liver metastases and right humeral metastases, and has been treated with radiotherapy for bone metastases and has maintained CR. After TACE in November 2017, he received 9 rounds of lanreotide treatment. In December 2018, he again had liver metastases and lymph node recurrence. He has been treated with everolimus treatment again and is maintaining SD in outpatient treatment.
胰腺神经内分泌肿瘤（p-NET）是一种相对罕见的疾病，治疗方式为多学科综合治疗，包括手术切除、局部治疗、放疗和化疗。我们报告一例通过多学科治疗实现长期生存的病例。该病例为一名47岁男性。因诊断为胰尾肿瘤转诊至我院，并于2008年5月接受了胰体尾切除术。病理结果诊断为p-NET G1。在接受3次经动脉化疗栓塞（TACE）治疗及1次因复发性肝转移行部分肝切除术后，2014年8月发现多处肝转移和淋巴结转移。经依维莫司治疗，联合TACE治疗后，淋巴结疗效判定为完全缓解（CR），肝脏病灶为CR。2017年7月，出现多处肝转移和右肱骨转移，接受了骨转移放疗并维持CR状态。2017年11月TACE治疗后，接受了9轮兰瑞肽治疗。2018年12月，再次出现肝转移和淋巴结复发。再次接受依维莫司治疗，门诊治疗维持病情稳定（SD）。
