Meurer M, Millns J L, Rogers R S, Jordon R E
Arch Dermatol. 1977 Nov;113(11):1520-4.
The conditions of ten patients were diagnosed as pemphigus vulgaris limited to the oral cavity. In eight patients the histopathologic findings were consistent with oral pemphigus. Direct immunofluorescence demonstrated intercellular substance (ICS) deposition of C3 either alone or in combination with IgG, IgA, IgM, C4, C1q, properdin, and factor B in all nine patients tested. Circulating ICS antibodies were detected initially in eight of the ten patients, nine of whom had positive titers at a later date, without subsequent development of cutaneous lesions. Physicians should be alerted to a diagnosis of pemphigus in patients who have chronic erosive disease confined to the oral cavity. Prompt diagnosis by means of routine histopathologic and immunofluorescence studies followed by early initiation of treatment are warranted.
10例患者的病情被诊断为局限于口腔的寻常型天疱疮。8例患者的组织病理学检查结果与口腔天疱疮相符。直接免疫荧光显示，在所有9例接受检测的患者中，细胞间物质（ICS）有C3沉积，或单独沉积，或与IgG、IgA、IgM、C4、C1q、备解素和B因子联合沉积。最初在10例患者中的8例检测到循环ICS抗体，其中9例在随后的时间里滴度呈阳性，且未出现皮肤损害。对于患有局限于口腔的慢性糜烂性疾病的患者，医生应警惕天疱疮的诊断。通过常规组织病理学和免疫荧光研究进行快速诊断，随后尽早开始治疗是必要的。
