Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.
Front Endocrinol (Lausanne). 2021 Mar 11;12:639592. doi: 10.3389/fendo.2021.639592. eCollection 2021.
Preeclampsia (PE) is a serious pregnancy-related disease, and patients usually present with a high inflammatory response. Previous studies have suggested that aspirin (ASP) may have a role in alleviating the pathogenesis of preeclampsia. However, whether ASP can improve kidney damage and the mechanism for improving it is currently unclear. Here we optimized a lipopolysaccharide (LPS)-induced PE mouse model to identify the role of ASP in renal protection. We found that ASP treatment ameliorated LPS-induced renal failure and pathological changes, the tubular injury was significantly attenuated by ASP. Administration of ASP decreased the renal expression of pro-inflammatory factors, resulting in reduced kidney inflammation. The number of GALECTIN-3-positive cells was reduced, and the up-regulation of IL-6 and TNF-α was decreased. In addition, ASP also suppressed renal cell apoptosis and oxidative stress. An study indicated that ASP relieved LPS-induced HK-2 cell damage by inhibiting WNT5A/NF-κB signaling. Collectively, our data suggest that ASP is a useful therapeutic option for PE-related kidney injury.
子痫前期（PE）是一种严重的妊娠相关疾病，患者通常表现出高度的炎症反应。先前的研究表明，阿司匹林（ASP）可能在缓解子痫前期的发病机制中发挥作用。然而，ASP 是否能改善肾脏损伤以及改善的机制目前尚不清楚。在这里，我们优化了脂多糖（LPS）诱导的 PE 小鼠模型，以确定 ASP 在肾脏保护中的作用。我们发现 ASP 治疗改善了 LPS 诱导的肾功能衰竭和病理变化，ASP 显著减轻了肾小管损伤。ASP 降低了肾脏中促炎因子的表达，导致肾脏炎症减少。GALECTIN-3 阳性细胞的数量减少，IL-6 和 TNF-α 的上调减少。此外，ASP 还抑制了肾细胞凋亡和氧化应激。一项研究表明，ASP 通过抑制 WNT5A/NF-κB 信号通路缓解 LPS 诱导的 HK-2 细胞损伤。综上所述，我们的数据表明，ASP 是治疗与子痫前期相关的肾脏损伤的一种有效治疗选择。
