• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高血压与肠道微生物群相关性的研究进展

Research Progress on the Correlation Between Hypertension and Gut Microbiota.

作者信息

Cui Xiaomei, Zhang Ting, Xie Tao, Guo Fang-Xi, Zhang Yu-Ying, Deng Yuan-Jia, Wang Qi, Guo Yi-Xing, Dong Ming-Hua, Luo Xiao-Ting

机构信息

Key Laboratory of Cardio Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, People's Republic of China.

School of Public Health and Health Management, Gannan Medical University, Ganzhou, People's Republic of China.

出版信息

J Multidiscip Healthc. 2024 May 16;17:2371-2387. doi: 10.2147/JMDH.S463880. eCollection 2024.

DOI:10.2147/JMDH.S463880
PMID:38770171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11104380/
Abstract

Among cardiovascular diseases, hypertension is the most important risk factor for morbidity and mortality worldwide, and its pathogenesis is complex, involving genetic, dietary and environmental factors. The characteristics of the gut microbiota can vary in response to increased blood pressure (BP) and influence the development and progression of hypertension. This paper describes five aspects of the relationship between hypertension and the gut microbiota, namely, the different types of gut microbiota, metabolites of the gut microbiota, sympathetic activation, gut-brain interactions, the effects of exercise and dietary patterns and the treatment of the gut microbiota through probiotics, faecal microbiota transplantation (FMT) and herbal remedies, providing new clues for the future prevention of hypertension. Diet, exercise and traditional Chinese medicine may contribute to long-term improvements in hypertension, although the effects of probiotics and FMT still need to be validated in large populations.

摘要

在心血管疾病中，高血压是全球发病和死亡的最重要危险因素，其发病机制复杂，涉及遗传、饮食和环境因素。肠道微生物群的特征会因血压升高而发生变化，并影响高血压的发生和发展。本文描述了高血压与肠道微生物群关系的五个方面，即肠道微生物群的不同类型、肠道微生物群的代谢产物、交感神经激活、肠-脑相互作用、运动和饮食模式的影响以及通过益生菌、粪便微生物群移植（FMT）和草药对肠道微生物群的治疗，为未来高血压的预防提供了新线索。饮食、运动和中药可能有助于高血压的长期改善，尽管益生菌和FMT的效果仍需在大量人群中得到验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/6bbcfad723de/JMDH-17-2371-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/cab637dbca0a/JMDH-17-2371-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/cc27ffd99931/JMDH-17-2371-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/58f7c7a1da4c/JMDH-17-2371-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/6bbcfad723de/JMDH-17-2371-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/cab637dbca0a/JMDH-17-2371-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/cc27ffd99931/JMDH-17-2371-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/58f7c7a1da4c/JMDH-17-2371-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c32/11104380/6bbcfad723de/JMDH-17-2371-g0004.jpg

相似文献

1
Research Progress on the Correlation Between Hypertension and Gut Microbiota.高血压与肠道微生物群相关性的研究进展
J Multidiscip Healthc. 2024 May 16;17:2371-2387. doi: 10.2147/JMDH.S463880. eCollection 2024.
2
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease.揭示肠道-心脏轴：探索肠道微生物群在心血管健康与疾病中的作用。
Ann Med Surg (Lond). 2024 Jan 18;86(5):2752-2758. doi: 10.1097/MS9.0000000000001744. eCollection 2024 May.
3
Unraveling mechanistic insights into the role of microbiome in neurogenic hypertension: A comprehensive review.解析微生物组在神经源性高血压中的作用的机制见解：全面综述。
Pathol Res Pract. 2023 Sep;249:154740. doi: 10.1016/j.prp.2023.154740. Epub 2023 Aug 6.
4
Dietary influences on the Dahl SS rat gut microbiota and its effects on salt-sensitive hypertension and renal damage.饮食对 Dahl SS 大鼠肠道微生物群的影响及其对盐敏感性高血压和肾脏损害的作用。
Acta Physiol (Oxf). 2021 Aug;232(4):e13662. doi: 10.1111/apha.13662. Epub 2021 Apr 26.
5
Gut microbiota and hypertension: association, mechanisms and treatment.肠道微生物群与高血压：关联、机制与治疗。
Clin Exp Hypertens. 2023 Dec 31;45(1):2195135. doi: 10.1080/10641963.2023.2195135.
6
Exploring the Gut Microbiota and Cardiovascular Disease.探索肠道微生物群与心血管疾病
Metabolites. 2021 Jul 29;11(8):493. doi: 10.3390/metabo11080493.
7
Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats.免疫系统在大鼠粪便微生物群移植诱导的血管功能和血压控制中的作用。
Acta Physiol (Oxf). 2019 Sep;227(1):e13285. doi: 10.1111/apha.13285. Epub 2019 Jun 2.
8
Gut microbiota and integrative traditional Chinese and western medicine in prevention and treatment of heart failure.肠道微生物群与中西医结合防治心力衰竭。
Phytomedicine. 2023 Aug;117:154885. doi: 10.1016/j.phymed.2023.154885. Epub 2023 May 22.
9
Beyond gut feelings: how the gut microbiota regulates blood pressure.超越直觉：肠道微生物群如何调节血压。
Nat Rev Cardiol. 2018 Jan;15(1):20-32. doi: 10.1038/nrcardio.2017.120. Epub 2017 Aug 24.
10
The gut microbiota and blood pressure in experimental models.肠道微生物群与实验模型中的血压。
Curr Opin Nephrol Hypertens. 2019 Mar;28(2):97-104. doi: 10.1097/MNH.0000000000000476.

引用本文的文献

1
The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review.肠道微生物群和膳食纤维通过与钠的相互作用在血压调节中的作用：一项叙述性综述。
Microorganisms. 2025 May 30;13(6):1269. doi: 10.3390/microorganisms13061269.
2
"Gut Microbiota as a Therapeutic Target for Hypertension: Challenges and Insights for Future Clinical Applications" "Gut Microbiota and Hypertension Therapy".“作为高血压治疗靶点的肠道微生物群：未来临床应用的挑战与见解” “肠道微生物群与高血压治疗”
Curr Hypertens Rep. 2025 Apr 22;27(1):14. doi: 10.1007/s11906-025-01331-w.
3

本文引用的文献

1
E3 Combined with E4 Improves LPS-Induced Intestinal Injury by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways .E3 与 E4 联合通过抑制 TLR4/NF-κB 和 MAPK 信号通路改善 LPS 诱导的肠道损伤。
J Agric Food Chem. 2023 Jun 14;71(23):8915-8930. doi: 10.1021/acs.jafc.3c00421. Epub 2023 May 31.
2
Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4.饮食丁酸可改善与肠道lachnospiraceae 28-4 细菌选择性增殖相关的代谢健康。
JCI Insight. 2023 Feb 22;8(4):e166655. doi: 10.1172/jci.insight.166655.
3
Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway and .
Probiotic Lactobacillus rhamnosus GG Alleviates Prehypertension and Restores Gut Health and Microbiota in NaCl-Induced Prehypertensive Rats.
益生菌鼠李糖乳杆菌GG可缓解盐诱导的高血压前期大鼠的高血压前期状态，并恢复其肠道健康和微生物群。
Probiotics Antimicrob Proteins. 2025 Apr 20. doi: 10.1007/s12602-025-10536-z.
4
in the Faecal Microbiota Demonstrates a Direct Association with Arterial Hypertension in Individuals of the Kazakh Population Without Insulin Resistance.在哈萨克族人群中，粪便微生物群与无胰岛素抵抗个体的动脉高血压呈直接关联。
Int J Environ Res Public Health. 2024 Nov 22;21(12):1546. doi: 10.3390/ijerph21121546.
5
Effect of fruits granola (Frugra®) consumption on blood pressure reduction and intestinal microbiome in patients undergoing hemodialysis.水果格兰诺拉麦片（Frugra®）摄入对血液透析患者血压降低和肠道微生物群的影响。
Hypertens Res. 2024 Nov;47(11):3214-3224. doi: 10.1038/s41440-024-01895-1. Epub 2024 Sep 19.
槲皮素通过TLR4/NF-κB/NLRP3信号通路有效改善脂多糖诱导的肠道炎症、细胞焦亡及屏障功能破坏。
Food Nutr Res. 2022 Dec 30;66. doi: 10.29219/fnr.v66.8948. eCollection 2022.
4
Exaggerated renal sympathetic nerve and pressor responses during spontaneously occurring motor activity in hypertensive rats.在自发性运动活动期间，高血压大鼠的肾交感神经和升压反应被夸大。
Am J Physiol Regul Integr Comp Physiol. 2023 Apr 1;324(4):R497-R512. doi: 10.1152/ajpregu.00271.2022. Epub 2023 Feb 13.
5
Microbiota: A potential orchestrator of antidiabetic therapy.微生物群：抗糖尿病治疗的潜在协调者。
Front Endocrinol (Lausanne). 2023 Jan 27;14:973624. doi: 10.3389/fendo.2023.973624. eCollection 2023.
6
Luteolin Attenuates Hypertension via Inhibiting NF-κB-Mediated Inflammation and PI3K/Akt Signaling Pathway in the Hypothalamic Paraventricular Nucleus.木犀草素通过抑制下丘脑室旁核 NF-κB 介导的炎症和 PI3K/Akt 信号通路减轻高血压。
Nutrients. 2023 Jan 18;15(3):502. doi: 10.3390/nu15030502.
7
Liuzijue training improves hypertension and modulates gut microbiota profile.六字诀训练可改善高血压并调节肠道微生物群谱。
Front Cardiovasc Med. 2023 Jan 25;10:1075084. doi: 10.3389/fcvm.2023.1075084. eCollection 2023.
8
Retrospective Evaluation of Nosocomial Bacterial Infections and Their Antimicrobial Resistance Patterns Among Hospitalized Patients in Mogadishu, Somalia.索马里摩加迪沙住院患者医院获得性细菌感染及其抗菌药物耐药模式的回顾性评估
Infect Drug Resist. 2023 Feb 1;16:705-720. doi: 10.2147/IDR.S398387. eCollection 2023.
9
Quanduzhong capsules for the treatment of grade 1 hypertension patients with low-to-moderate risk: A multicenter, randomized, double-blind, placebo-controlled clinical trial.豨莶通络胶囊治疗低中危1级高血压患者：一项多中心、随机、双盲、安慰剂对照临床试验
Front Pharmacol. 2023 Jan 10;13:1014410. doi: 10.3389/fphar.2022.1014410. eCollection 2022.
10
Zhijing powder manages blood pressure by regulating PI3K/AKT signal pathway in hypertensive rats.芷菁散通过调节高血压大鼠的PI3K/AKT信号通路来控制血压。
Heliyon. 2023 Jan 2;9(1):e12777. doi: 10.1016/j.heliyon.2022.e12777. eCollection 2023 Jan.