O-hara M, Esato K, Mohri H
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
J Cardiovasc Surg (Torino). 1988 May-Jun;29(3):268-76.
The purpose of this study was to investigate the effect of pancreatopeptidase E (Elastase) administration on the healing of anastomosed arteries. A segment of infrarenal aorta was resected and reanastomosed in rabbits. In the control group, rabbits were fed commercial chow (ORC 4). In the cholesterol group, rabbits were fed a diet of 1% cholesterol added to ORC 4. In the Elastase group, rabbits were fed the same diet as the cholesterol group but received intraabdominal injections of Elastase. The rabbits were kept for 4 months and the abdominal aorta was retrieved for examination. All anastomosed aortas were patent. The cholesterol group developed aneurysmal dilatation in one and stenosis of the anastomosed sites due to hypergranulation in the remaining rabbits. Neither aneurysmal nor stenotic changes were detected in the other groups. We concluded that the administration of Elastase suppressed cholesterol induced atherosclerotic changes at the anastomotic sites in these animals.
本研究的目的是探讨给予胰肽酶E（弹性蛋白酶）对吻合动脉愈合的影响。在兔身上切除一段肾下主动脉并进行重新吻合。对照组的兔子喂食市售饲料（ORC 4）。胆固醇组的兔子喂食添加了1%胆固醇的ORC 4饲料。弹性蛋白酶组的兔子喂食与胆固醇组相同的饲料，但接受腹腔内注射弹性蛋白酶。将兔子饲养4个月后取出腹主动脉进行检查。所有吻合的主动脉均保持通畅。胆固醇组有1只出现动脉瘤样扩张，其余兔子因吻合部位肉芽组织增生而出现吻合部位狭窄。其他组均未检测到动脉瘤样或狭窄性改变。我们得出结论，给予弹性蛋白酶可抑制这些动物吻合部位胆固醇诱导的动脉粥样硬化改变。
