Kouchi Y, Esato K, O-Hara M, Zempo N
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
J Vasc Surg. 1992 Aug;16(2):232-8.
This study investigated the effect of prostaglandin I2 analogue (TRK-100) on the healing of arterial anastomoses. The infrarenal abdominal aorta was divided and reanastomosed immediately in rabbits. A control group of rabbits were fed commercial rabbit food (ORC 4); a cholesterol group of rabbits were fed a diet with 1% cholesterol added to ORC 4; and a TRK group of rabbits received the same diet as the cholesterol group, but TRK-100 was given subcutaneously at a dose of 0.3 mg (TRK-I group) or 1.0 mg (TRK-II group) every other day. After 3 months a blood sample was taken for biochemical analysis, and the abdominal aorta was harvested for histologic examination. The serum lipid and thromboxane B2 concentrations and the thromboxane B2/6-keto prostaglandin F1 alpha ratio in the TRK groups were significantly lower than in the cholesterol group. The proliferative connective tissue did not cover the anastomotic suture line in either the control or the TRK groups. However, the suture line was covered completely by connective tissue in the cholesterol group. Intimal thickness in the cholesterol group was greater than in either the control or the TRK-II group (p less than 0.01 and p less than 0.05, respectively). These data suggest that TRK-100 may suppress intimal fibrous proliferation at anastomotic suture lines by a mechanism affecting the thromboxane B2/6-keto prostaglandin F1 alpha ratio.
本研究调查了前列腺素I2类似物（TRK - 100）对动脉吻合口愈合的影响。在兔子身上将肾下腹主动脉进行分离并立即重新吻合。一组对照组兔子喂食商业兔粮（ORC 4）；一组胆固醇组兔子喂食添加了1%胆固醇的ORC 4饮食；一组TRK组兔子接受与胆固醇组相同的饮食，但每隔一天皮下注射剂量为0.3毫克的TRK - 100（TRK - I组）或1.0毫克（TRK - II组）。3个月后采集血样进行生化分析，并摘取腹主动脉进行组织学检查。TRK组的血清脂质、血栓素B2浓度以及血栓素B2/6 - 酮前列腺素F1α比值均显著低于胆固醇组。在对照组和TRK组中，增殖性结缔组织均未覆盖吻合缝线。然而，在胆固醇组中，缝线被结缔组织完全覆盖。胆固醇组的内膜厚度大于对照组和TRK - II组（分别为p＜0.01和p＜0.05）。这些数据表明，TRK - 100可能通过影响血栓素B2/6 - 酮前列腺素F1α比值的机制抑制吻合缝线处的内膜纤维增生。
