Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Front Endocrinol (Lausanne). 2021 Mar 15;12:649718. doi: 10.3389/fendo.2021.649718. eCollection 2021.
Circulating osteoglycin may facilitate the crosstalk between bone and pancreas to empower adaptation of bone mass to whole body energy balance. We aimed to examine whether osteoglycin is associated with bone and metabolic parameters and if osteoglycin levels differ between patients with type 1 and 2 diabetes (T1D and T2D).
A cross-sectional study of 190 patients with diabetes mellitus and stable hemoglobin A1c (HbA1c) (97 T1D and 93 T2D) was conducted. S-osteoglycin was analyzed by ELISA. Unpaired t-tests were performed to test differences between patients with T1D and T2D and linear regression analyses were performed to investigate associations between osteoglycin, glycemic markers, bone turnover markers and characteristics.
S-osteoglycin did not differ between patients with T1D and T2D (p=0.10). No associations were present between osteoglycin and age, gender, microvascular complications, HbA1c, or plasma glucose in T1D or T2D patients (p>0.05 for all). S-osteoglycin was not associated with levels of bone turnover markers (C-terminal cross-linked telopeptide of type-I collagen (CTX), P-procollagen type 1 amino terminal propeptide (P1NP), P-osteocalcin (OC), P-sclerostin, S-osteoprotegerin (OPG) or S-Receptor Activator of Nuclear factor Kappa beta Ligand (RANKL)) in neither T1D or T2D patients (p>0.05 for all).
Osteoglycin levels were similar in T1D and T2D patients. Osteoglycin did not correlate with glucose, HbA1c or any other biochemical marker of bone turnover. Thus, we did not find evidence supporting the existence of an osteoglycin-bone-pancreas axis.
ClinicalTrials.gov, identifier NCT01870557.
循环骨糖蛋白可能促进骨骼和胰腺之间的交流，从而增强骨骼对全身能量平衡的适应能力。我们旨在研究骨糖蛋白是否与骨代谢参数相关，以及 1 型和 2 型糖尿病（T1D 和 T2D）患者之间的骨糖蛋白水平是否存在差异。
对 190 例糖尿病患者（97 例 T1D 和 93 例 T2D）进行横断面研究。通过 ELISA 分析 S-骨糖蛋白。采用未配对 t 检验比较 T1D 和 T2D 患者之间的差异，采用线性回归分析研究骨糖蛋白与血糖标志物、骨转换标志物和特征之间的关系。
T1D 和 T2D 患者的 S-骨糖蛋白水平无差异（p=0.10）。在 T1D 或 T2D 患者中，骨糖蛋白与年龄、性别、微血管并发症、HbA1c 或血浆葡萄糖均无相关性（p>0.05）。S-骨糖蛋白与骨转换标志物（I 型胶原 C 端交联肽（CTX）、I 型前胶原氨基端前肽（P1NP）、骨钙素（OC）、骨硬化蛋白、S-骨保护素（OPG）或 S-核因子 Kappa 受体激活剂配体（RANKL））水平均无相关性（p>0.05）。
T1D 和 T2D 患者的骨糖蛋白水平相似。骨糖蛋白与葡萄糖、HbA1c 或任何其他骨转换的生化标志物均无相关性。因此，我们没有发现支持骨糖蛋白-骨骼-胰腺轴存在的证据。
ClinicalTrials.gov，标识符 NCT01870557。
