Department of Pediatrics, M. Tettamanti Research Center, University of Milano-Bicocca, Monza, Italy.
The Peter Gorer Department of Immunobiology, Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom.
Front Immunol. 2021 Mar 15;12:631279. doi: 10.3389/fimmu.2021.631279. eCollection 2021.
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both and .
组织工程在再生医学、药物测试以及血液发生在健康和疾病中的建模方面提供了多种机会。重现支持白细胞发育的生理微环境的组织对于忠实地模拟免疫细胞的发育至关重要。造血器官的形成受到由多种细胞贡献定义的空间组织龛的影响。免疫龛的一个共同特征是存在间充质基质细胞，它们在组织龛的发育、维持和功能中具有独特的作用。在这里，我们回顾了利用基质细胞来工程人工免疫龛和造血类器官的挑战和机遇，这些类器官可以重现白细胞的个体发生。
