Deng Danni, Mo Yi, Xue Lian, Shao Naiyuan, Cao Jie
Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China.
Clinical Medical Research Center, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China.
Exp Ther Med. 2021 May;21(5):491. doi: 10.3892/etm.2021.9922. Epub 2021 Mar 16.
Gliomas account for 50% of primary brain tumours in the central nervous system. Small ubiquitin-like modifier 1 pseudogene 3 (SUMO1P3), a newly identified long non-coding RNA (lncRNA), serves an oncogenic role in various types of cancer. The aim of the present study was to investigate the effect of SUMO1P3 on glioma progression. The results demonstrated that SUMO1P3 expression was upregulated in glioma tissues and cell lines. Furthermore, SUMO1P3 was associated with a poor overall survival of patients with glioma. The results of the cell proliferation and flow cytometry assays demonstrated that SUMO1P3-knockdown suppressed cell proliferation and cell cycle. The results of the wound healing and Transwell assays demonstrated that SUMO1P3-knockdown significantly repressed cell migration and invasion. In addition, SUMO1P3 promoted glioma by regulating the expression levels of β-catenin, cyclin-D1, N-cadherin and E-cadherin. Overall, the results of the present study suggested that SUMO1P3 may act as an oncogene by regulating cell proliferation, cell cycle, cell migration and invasion in glioma, and may represent a novel diagnostic biomarker and therapeutic target for glioma.
胶质瘤占中枢神经系统原发性脑肿瘤的50%。小泛素样修饰因子1假基因3（SUMO1P3）是一种新发现的长链非编码RNA（lncRNA），在多种类型的癌症中发挥致癌作用。本研究的目的是探讨SUMO1P3对胶质瘤进展的影响。结果表明，SUMO1P3在胶质瘤组织和细胞系中表达上调。此外，SUMO1P3与胶质瘤患者较差的总生存期相关。细胞增殖和流式细胞术检测结果表明，敲低SUMO1P3可抑制细胞增殖和细胞周期。伤口愈合和Transwell检测结果表明，敲低SUMO1P3可显著抑制细胞迁移和侵袭。此外，SUMO1P3通过调节β-连环蛋白、细胞周期蛋白D1、N-钙黏蛋白和E-钙黏蛋白的表达水平促进胶质瘤。总体而言，本研究结果表明，SUMO1P3可能通过调节胶质瘤细胞的增殖、细胞周期、细胞迁移和侵袭而作为一种癌基因发挥作用，并且可能代表一种新的胶质瘤诊断生物标志物和治疗靶点。
