Zhou Kun, Chang Yinxia, Han Bo, Li Rui, Wei Yanming
Shanxi Institute of Energy, Taiyuan, Shanxi 030600, P.R. China.
College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China.
Exp Ther Med. 2021 May;21(5):499. doi: 10.3892/etm.2021.9930. Epub 2021 Mar 17.
Triptolide is the main bioactive constituent isolated from the Chinese herb Hook F., which possesses a variety of pharmacological properties. MicroRNAs (miRNAs/miRs) are short non-coding RNAs that regulate gene expression post-transcriptionally. miRNAs are implicated in several intracellular processes, whereby their dysregulation contributes to pathogenesis of various diseases. Thus, miRNAs have great potential as biomarkers and therapeutic targets for diseases, and are implicated in drug treatment. Previous studies have reported that specific miRNAs are targeted, and their expression levels can be altered following exposure to triptolide. Thus, miRNAs are emerging as crucial mediators in the pharmacological activities of triptolide. The present review summarizes current literature on miRNAs as target molecules in the pharmacological activities of triptolide, including antitumor, anti-inflammatory, immunosuppressive, renal protective, cardioprotective, antiangiogenesis activities and multiorgan toxicity effects. In addition, the diverse signaling pathways involved are discussed to provide a comprehensive understanding of the underlying molecular mechanisms of triptolide in the regulation of target miRNAs.
雷公藤甲素是从中药雷公藤中分离出的主要生物活性成分，具有多种药理特性。微小RNA（miRNA/miR）是短链非编码RNA，可在转录后调节基因表达。miRNA参与多种细胞内过程，其失调会导致各种疾病的发病机制。因此，miRNA作为疾病的生物标志物和治疗靶点具有巨大潜力，并与药物治疗有关。先前的研究报道，特定的miRNA是靶点，暴露于雷公藤甲素后其表达水平会发生改变。因此，miRNA正在成为雷公藤甲素药理活性的关键介质。本综述总结了当前关于miRNA作为雷公藤甲素药理活性靶分子的文献，包括抗肿瘤、抗炎、免疫抑制、肾脏保护、心脏保护、抗血管生成活性和多器官毒性作用。此外，还讨论了所涉及的多种信号通路，以全面了解雷公藤甲素调节靶miRNA的潜在分子机制。
