Ziaei Samira, Halaby Reginald
Montclair State University, Department of Biology, 1 Normal Avenue, Montclair NJ 07043, USA.
Avicenna J Phytomed. 2016 Mar-Apr;6(2):149-64.
Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. However, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. In this review, we discuss the autoimmune disorders and inflammatory conditions that are currently treated with triptolide. Triptolide also possesses anti-tumorigenic effects. We discuss the toxicity of various triptolide derivatives and offer suggestions to improve its safety. This study also examines the clinical trials that have investigated the efficacy of triptolide. Our aim is to examine the mechanisms that are responsible for the immunosuppressive, anti-inflammatory, and anti-cancer effects of triptolide.
The present review provides a comprehensive summary of the literature with respect to the immunosuppressive, anti-inflammatory, and anti-cancer properties of triptolide.
Triptolide possesses immunosuppressive, anti-inflammatory, and anti-cancer effects.
Triptolide can be used alone or in combination with existing therapeutic modalities as novel treatments for autoimmune disorders, cancers, and for immunosuppression.
雷公藤甲素是雷公藤的活性成分，在传统中药中用于治疗自身免疫性和炎症性疾病已有两百多年历史。然而，雷公藤甲素发挥免疫抑制和抗炎作用的具体机制尚不清楚。在本综述中，我们讨论了目前用雷公藤甲素治疗的自身免疫性疾病和炎症性疾病。雷公藤甲素还具有抗肿瘤作用。我们讨论了各种雷公藤甲素衍生物的毒性，并提出提高其安全性的建议。本研究还考察了探究雷公藤甲素疗效的临床试验。我们的目的是研究雷公藤甲素免疫抑制、抗炎和抗癌作用的机制。
本综述全面总结了雷公藤甲素免疫抑制、抗炎和抗癌特性的相关文献。
雷公藤甲素具有免疫抑制、抗炎和抗癌作用。
雷公藤甲素可单独使用或与现有治疗方法联合使用，作为治疗自身免疫性疾病、癌症和免疫抑制的新疗法。
