The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Memorial University of Newfoundland School of Medicine, Newfoundland and Labrador, Canada.
Oxid Med Cell Longev. 2021 Mar 13;2021:6657944. doi: 10.1155/2021/6657944. eCollection 2021.
Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus affecting various physiological processes of the nervous system. In this review, we have compiled various reported lncRNAs related to the growth and development of central and peripheral nerves and pathophysiology (including advanced nerve centers, spinal cord, and peripheral nervous system) and explained how these lncRNAs play regulatory roles through their interactions with target-coding genes. We believe that a full understanding of the regulatory function of lncRNAs in the nervous system will contribute to understand the molecular mechanism of changes after nerve injury and will contribute to discover new diagnostic markers and therapeutic targets for nerve injury diseases.
长链非编码 RNA（lncRNAs）因其在各种细胞过程中的调节作用而受到广泛关注。新兴研究表明，lncRNAs 在神经系统的生长和发育以及损伤和变性后表达程度不同，从而影响神经系统的各种生理过程。在这篇综述中，我们汇编了各种已报道的与中枢和周围神经的生长和发育以及病理生理学（包括高级神经中枢、脊髓和周围神经系统）相关的 lncRNAs，并解释了这些 lncRNAs 如何通过与靶编码基因的相互作用发挥调节作用。我们相信，充分了解 lncRNAs 在神经系统中的调节功能将有助于理解神经损伤后变化的分子机制，并有助于发现神经损伤疾病的新诊断标志物和治疗靶点。
