Chen Sisi, Geng Xinwei, Syeda Madiha Zahra, Huang Zhengming, Zhang Chao, Ying Songmin
International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Cell Dev Biol. 2021 Mar 15;9:657305. doi: 10.3389/fcell.2021.657305. eCollection 2021.
MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene mutations completely alter the role of MUS81 in human cancers. Here, we review the recent understanding of how MUS81 functions in tumors with distinct genetic backgrounds and discuss the potential therapeutic strategies targeting MUS81 in cancer.
MUS81复合物对特定DNA结构具有核酸内切酶活性，在DNA修复中发挥重要作用。研究证明，MUS81在哺乳动物的胚胎发育和细胞存活中并非必需。然而，研究中出现了一幅复杂的图景，其中不同的基因突变完全改变了MUS81在人类癌症中的作用。在这里，我们回顾了对MUS81在具有不同遗传背景的肿瘤中如何发挥作用的最新认识，并讨论了针对癌症中MUS81的潜在治疗策略。
