Casas Laurie A, Bell Michaela, Claytor Brannon, Ziegler Mary E, Widgerow Alan D
Aesthet Surg J Open Forum. 2020 Nov 18;3(1):ojaa052. doi: 10.1093/asjof/ojaa052. eCollection 2021 Jan.
Physicians strive to improve the postsurgical experience and optimize patient-reported recovery outcome measures (PROMs) following elective cosmetic surgical procedures. Our previous pilot feasibility study demonstrated that twice daily postoperative topical body treatment with tripeptide and hexapeptide (TransFORM Body Treatment with TriHex Technology [TFB, Alastin Skincare, Inc., Carlsbad, CA]) reduced PROMs of swelling, induration, soft tissue fibrosis, and pain as well as improved visible and palpable skin quality.
Evaluate whether adding a tripeptide/hexapeptide anhydrous gel (Regenerating Skin Nectar with TriHex Technology [RSN, Alastin Skincare, Inc., Carlsbad, CA]) pre- and post-procedure to the existing postsurgical regimen of TFB significantly improves 6 PROMs in patients undergoing neck and body contouring cosmetic surgical procedures.
Ten female patients underwent 15 neck and body contouring procedures and were blindly randomized to 1 of 2 topical treatment protocols (1 [TFB] and 2 [RSN/TFB]) pre- and post-procedure. Patient-reported scores of 5 skin parameters (skin discoloration, ecchymosis, edema, induration, and subcutaneous fibrous banding) and pain scores using the Visual Analog Scale were collected at 8 intervals for 12 weeks post-procedure.
The treatment side that used both topicals showed significantly reduced scores of edema, induration, and subcutaneous fibrous banding compared with the side that only used 1 topical, on days 5-7 and 10-14 ( < 0.05). All patients observed slower soft tissue recovery on the side that was treated with TFB alone and opted to break the code and use both topical treatments.
Patients had statistically significant improved patient-reported measures of skin edema, skin induration, and subcutaneous banding on the operated side that used both topicals.
医生们致力于改善择期美容手术后的体验，并优化患者报告的恢复结果指标（PROMs）。我们之前的初步可行性研究表明，术后每天两次使用三肽和六肽进行局部身体治疗（采用TriHex技术的TransFORM身体护理[TFB，阿拉斯汀皮肤护理公司，加利福尼亚州卡尔斯巴德]）可降低肿胀、硬结、软组织纤维化和疼痛的PROMs，并改善可见和可触及的皮肤质量。
评估在现有的TFB术后治疗方案基础上，术前和术后添加三肽/六肽无水凝胶（采用TriHex技术的再生肌肤精华液[RSN，阿拉斯汀皮肤护理公司，加利福尼亚州卡尔斯巴德]）是否能显著改善接受颈部和身体轮廓塑形美容手术患者的6项PROMs。
10名女性患者接受了15次颈部和身体轮廓塑形手术，并在术前和术后被随机分为2种局部治疗方案中的1种（1 [TFB]和2 [RSN/TFB]）。术后12周内，每隔8个时间点收集患者报告的5项皮肤参数（皮肤变色、瘀斑、水肿、硬结和皮下纤维带）评分以及使用视觉模拟量表的疼痛评分。
在术后第5 - 7天和第10 - 14天，与仅使用1种局部用药的一侧相比，同时使用两种局部用药的治疗侧水肿、硬结和皮下纤维带的评分显著降低（<0.05）。所有患者都观察到仅使用TFB治疗的一侧软组织恢复较慢，因此选择解密并使用两种局部治疗。
在同时使用两种局部用药的手术侧，患者报告的皮肤水肿、皮肤硬结和皮下带的测量指标在统计学上有显著改善。
