Department of Biotechnology, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
CHU Rennes, Inserm, LTSI (Laboratoire de Traitement du Signal de l'Image), France.
J Pharm Pharmacol. 2021 Mar 1;73(1):93-97. doi: 10.1093/jpp/rgaa024.
The erythrinan alkaloids erythravine and 11α-hydroxy-erythravine from Erythrina verna (Vell.) have been extensively investigated for their anxiolytic and anticonvulsant effects. Both are structurally similar to the erythrartine that also exhibit anxiolytic effects, but there is no report on its anticonvulsant potential. Since some anxiolytic drugs can be useful in the management of epileptic seizures, we investigated whether erythrartine could prevent seizures induced by different chemoconvulsants.
Experiments were performed using different concentrations of erythrartine injected via intracerebroventricular in rats submitted to pilocarpine, kainic acid, pentylenetetrazol or picrotoxin-induced seizures. Moreover, the rotarod test was performed to verify the effects of erythrartine on animal motor coordination.
Our data showed for the first time that erythrartine prevented the occurrence of seizures induced by all of the chemoconvulsants tested and did not affect locomotor performance neither produced sedative effect on animals.
Obtained results validate the ethnopharmacological significance of E. verna and provide new information on erythrartine, another erythrinian alkaloid of biotechnological and medicinal interest.
从 Vernonia erythrina（Vell.）中提取的 Erythrinan 生物碱 Erythravine 和 11α-羟基-Erythravine 已被广泛研究其抗焦虑和抗惊厥作用。两者在结构上与同样具有抗焦虑作用的 Erythrartine 相似，但尚未有关于其抗惊厥潜力的报道。由于一些抗焦虑药物可用于癫痫发作的管理，我们研究了 Erythrartine 是否可以预防不同化学惊厥剂引起的癫痫发作。
通过向大鼠脑室内注射不同浓度的 Erythrartine ，进行了实验，这些大鼠经历了毛果芸香碱、海人酸、戊四氮或士的宁诱导的癫痫发作。此外，还进行了旋转棒试验以验证 Erythrartine 对动物运动协调的影响。
我们的数据首次表明，Erythrartine 可预防所有测试的化学惊厥剂引起的癫痫发作，并且对动物的运动表现没有影响，也没有产生镇静作用。
获得的结果验证了 Vernonia erythrina 的民族药理学意义，并为另一种生物技术和药用有价值的 Erythrinan 生物碱 Erythrartine 提供了新信息。
