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从夹竹桃科植物 E.multungu 的花中提取的生物碱 Erysothrine:评估其抗惊厥和抗焦虑潜力。

Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.

机构信息

Department of Biotechnology, University of Ribeirão Preto, Brazil.

出版信息

Epilepsy Behav. 2012 Mar;23(3):205-12. doi: 10.1016/j.yebeh.2012.01.003. Epub 2012 Feb 29.

Abstract

In this study, we isolated the alkaloid erysothrine from the hydroalcoholic extract of flowers from E. mulungu and screened for its anticonvulsant and anxiolytic actions based on neuroethological and neurochemical experiments. Our results showed that the administration of erysothrine inhibited seizures evoked by bicuculline, PTZ, NMDA and most remarkably, kainic acid. Also, erysothrine induced an increase in the number of entries but not in the time spent in the open arms of the EPM. However, we did not notice any alterations in the light-dark choice or in the open-field tests. In preliminary neurochemistry tests, we also showed that erysothrine (0.001-10 μg/mL) did not alter the GABA or glutamate synaptossomal uptake and binding. Altogether, our results describe an alkaloid with anticonvulsant activity and mild anxiolytic activity that might be considered well tolerated as it does not alter the general behavior of the animals in the used doses.

摘要

在这项研究中,我们从 E. mulungu 的花的水醇提取物中分离出生物碱赤松宁,并根据神经行为学和神经化学实验筛选其抗惊厥和抗焦虑作用。我们的结果表明,赤松宁的给药抑制了由印防己毒素、PTZ、NMDA 引起的惊厥,最显著的是,红藻氨酸。此外,赤松宁诱导进入次数增加,但在 EPM 的开放臂中花费的时间没有增加。然而,我们没有注意到在明暗选择或开阔场测试中有任何变化。在初步的神经化学测试中,我们还表明,赤松宁(0.001-10μg/ml)不改变 GABA 或谷氨酸突触摄取和结合。总的来说,我们的结果描述了一种具有抗惊厥活性和轻度抗焦虑活性的生物碱,它可能被认为是耐受良好的,因为它不会改变动物在使用剂量下的一般行为。

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