Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, P. R. China.
Rev Cardiovasc Med. 2021 Mar 30;22(1):159-165. doi: 10.31083/j.rcm.2021.01.238.
Coronavirus Disease 2019 (COVID-19) originated in Wuhan, China in December 2019 and rapidly spread worldwide. Herein, we conducted a systematic review and meta-analysis to find the association between COVID-19 and cardiovascular complications. We conducted a systematic literature search of the PubMed and Embase databases from 01 December 2019 to 30 November 2020. We then statistically analyzed the incidence of cardiovascular complications in COVID-19 patients. We included 3044 confirmed COVID-19 cases from 12 studies. The most common cardiovascular complications in COVID-19 patients were myocardial injury (21.2%, 95% CI 12.3-30.0%) and arrhythmia (15.3%, 95% CI 8.4-22.3%), followed by heart failure (14.4%, 95% CI 5.7-23.1%) and acute coronary syndrome (1.0%, 95% CI 0.5-1.5%). The pooled incidence of heart failure, arrhythmia and myocardial injury in non-survivors were 47.8% (95% CI 41.4-54.2%), 40.3% (95% CI 1.6-78.9%) and 61.7% (95% CI 46.8-76.6%), respectively. Also, the data separately showed significantly higher incidence of heart failure and cardiac injury in non-survivors (relative risks = 5.13, 95% CI 2.46-10.7, Z = 4.36, = 0.017) and (relative risks = 6.91, 95% CI 3.19-14.95, Z = 4.91, = 0.009). Myocardial injury and arrhythmia were the most common complications in COVID-19 patients. Myocardial injury and heart failure were more common in patients who died, regardless of a history of cardiovascular disease. The incidence of heart failure and myocardial injury were higher in non-survivors compared to the survivors. Accordingly, in addition to basic support, cardiac reactions of patients with confirmed COVID-19 with or without underlying cardiovascular diseases should be closely monitored.
新型冠状病毒病 2019（COVID-19）于 2019 年 12 月在中国武汉起源，并迅速在全球范围内传播。在此，我们进行了一项系统评价和荟萃分析，以寻找 COVID-19 与心血管并发症之间的关联。我们对 2019 年 12 月 1 日至 2020 年 11 月 30 日期间的 PubMed 和 Embase 数据库进行了系统文献检索。然后，我们对 COVID-19 患者心血管并发症的发生率进行了统计学分析。我们纳入了来自 12 项研究的 3044 例确诊的 COVID-19 病例。COVID-19 患者最常见的心血管并发症是心肌损伤（21.2%，95%CI 12.3-30.0%）和心律失常（15.3%，95%CI 8.4-22.3%），其次是心力衰竭（14.4%，95%CI 5.7-23.1%）和急性冠状动脉综合征（1.0%，95%CI 0.5-1.5%）。非幸存者心力衰竭、心律失常和心肌损伤的合并发生率分别为 47.8%（95%CI 41.4-54.2%）、40.3%（95%CI 1.6-78.9%）和 61.7%（95%CI 46.8-76.6%）。此外，数据分别显示非幸存者心力衰竭和心肌损伤的发生率明显更高（相对风险=5.13，95%CI 2.46-10.7，Z=4.36， =0.017）和（相对风险=6.91，95%CI 3.19-14.95，Z=4.91， =0.009）。心肌损伤和心律失常是 COVID-19 患者最常见的并发症。无论是否存在心血管疾病史，心力衰竭和心肌损伤在死亡患者中更为常见。与幸存者相比，非幸存者心力衰竭和心肌损伤的发生率更高。因此，除了基本支持外，还应密切监测确诊 COVID-19 患者（无论是否有基础心血管疾病）的心脏反应。
