State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
University of Science and Technology of China, Hefei, 230026, P. R. China.
ACS Nano. 2021 Apr 27;15(4):7638-7648. doi: 10.1021/acsnano.1c01194. Epub 2021 Apr 1.
Covalent organic frameworks (COFs) have shown great potential in catalysis and the biomedical fields, but monodisperse COFs with tunable sizes are hard to obtain. Herein, we successfully developed a series of COFs based on electron donor-acceptor strategy in mild conditions. The synthetic COFs exhibit excellent colloidal stability with uniform spherical morphology. The sizes can be flexibly adjusted by the amount of catalyst, and the absorption spectra also vary with the sizes. By changing the electron-donating ability of the monomers, the corresponding COFs possess a wide range of absorption spectra, which can be even extended to the second near-infrared biowindow. The obtained COFs possess potent photothermal activity under laser irradiation, and could inhibit the growth of tumors effectively. This work provides a strategy for the synthesis of monodisperse COFs with variable absorption for their potential applications.
共价有机框架（COFs）在催化和生物医学领域显示出巨大的潜力，但具有可调尺寸的单分散 COFs 很难获得。在此，我们在温和条件下成功地基于电子给体-受体策略开发了一系列 COFs。合成的 COFs 具有优异的胶体稳定性和均匀的球形形态。通过催化剂的用量可以灵活地调节尺寸，吸收光谱也随尺寸而变化。通过改变单体的供电子能力，相应的 COFs 具有广泛的吸收光谱，甚至可以扩展到第二个近红外生物窗口。所得到的 COFs 在激光照射下具有很强的光热活性，能够有效地抑制肿瘤的生长。这项工作为合成具有可变吸收的单分散 COFs 提供了一种策略，为它们的潜在应用提供了可能。
