Pharmacology, Burdwan Medical College, Burdwan, 713104, India.
Radiation Oncology, Burdwan Medical College, Burdwan, 713104, India.
Future Oncol. 2021 Jun;17(16):2041-2056. doi: 10.2217/fon-2020-0834. Epub 2021 Apr 1.
Comparison of efficacy, safety and sedation between two doses of olanzapine in the control of chemotherapy-induced nausea and vomiting (CINV). A prospective, randomized, double-blind, controlled study was conducted, enrolling 68 patients receiving a single-day cycle of high and moderately emetogenic chemotherapy. Patients received either of olanzapine 5 mg or 10 mg from day 1 through 3 in addition to ondansetron and dexamethasone. Control of CINV, nausea, sedation, quality of life (QoL) and adverse events were compared. Nausea, emesis control and improvement of QoL were similar in both groups. Sedation severity was 133% higher with 10 mg olanzapine. Lower dose olanzapine is effective to control CINV with significantly reduced sedation.
两种剂量奥氮平治疗化疗所致恶心呕吐（CINV）的疗效、安全性和镇静作用比较。一项前瞻性、随机、双盲、对照研究纳入了 68 例接受高致吐性和中致吐性化疗 1 天周期的患者。患者在第 1 天至第 3 天接受奥氮平 5mg 或 10mg 联合昂丹司琼和地塞米松治疗。比较了两组患者的 CINV 控制情况、恶心、镇静、生活质量（QoL）和不良反应。两组患者的恶心、呕吐控制和 QoL 改善情况相似。奥氮平 10mg 组镇静严重程度增加了 133%。低剂量奥氮平可有效控制 CINV，且镇静作用明显降低。
