Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
Expert Rev Vaccines. 2021 May;20(5):601-610. doi: 10.1080/14760584.2021.1908134. Epub 2021 Apr 1.
Seasonal influenza vaccine coverage remains low in China due to possible influenza vaccine hesitancy (IVH) and practical issues. We sought to investigate IVH and its determinants among children's guardians and the elderly for a better understanding of the situation and for future intervention.
We performed two cross-sectional studies to identify the profiles and determinants of IVH using stratified cluster random sampling in an eastern China province in 2019.
Of the 1564 guardians and 522 elders, 43.2% (95%CI: 40.4-46.0%) of guardians and 33.5% of elders (95%CI: 29.5-37.6%) had IVH. 'From rural area' (odds ratio: 1.36), 'don't know government recommendation for flu vaccination' (1.39), 'don't know flu vaccine is vaccinated annually' (1.93), and 'family members (0.22), friends and neighbors had positive attitude toward flu vaccine' (0.58) were related factors of the guardians' IVH. 'Aged 70-79 years' (0.46), 'had flu before' (0.35) and 'once had been vaccinated' (0.42) were related to the elderly's IVH.
Poor awareness of influenza and vaccination, relatives' negative/positive attitude, lack of government recommendations, anxiety about vaccine quality, and practical issues such as short supply are related to IVH in China. Precision education aimed at hesitancy in wider groups is anticipated to increase vaccine confidence and coverage in influenza-vulnerable groups.
由于可能存在流感疫苗犹豫（IVH）和实际问题，中国的季节性流感疫苗接种率仍然较低。我们旨在调查儿童监护人及老年人中的 IVH 及其决定因素，以便更好地了解情况并进行未来干预。
我们在 2019 年在中国东部省份进行了两项横断面研究，采用分层整群随机抽样方法确定 IVH 的特征和决定因素。
在 1564 名监护人及 522 名老年人中，43.2%（95%CI：40.4-46.0%）的监护人及 33.5%（95%CI：29.5-37.6%）存在 IVH。“来自农村地区”（比值比：1.36）、“不知道政府对流感疫苗接种的推荐”（1.39）、“不知道流感疫苗每年接种”（1.93）以及“家庭成员（0.22）、朋友和邻居对流感疫苗持积极态度”（0.58）是监护人 IVH 的相关因素。“年龄 70-79 岁”（0.46）、“曾患过流感”（0.35）和“曾接种过疫苗”（0.42）与老年人的 IVH 相关。
对流感和疫苗接种的认识不足、亲属的消极/积极态度、缺乏政府建议、对疫苗质量的担忧以及供应短缺等实际问题与中国的 IVH 有关。针对更广泛人群的犹豫进行精准教育，有望提高流感疫苗在易感人群中的信心和接种率。
