Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.
Department of Histopathology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.
Skeletal Radiol. 2021 Oct;50(10):1963-1980. doi: 10.1007/s00256-021-03769-w. Epub 2021 Apr 1.
Myxoid liposarcoma (MLS) accounts for approximately 30% of all liposarcomas. The majority are intermediate-grade tumours, but the presence of >5% round cell component renders it a high-grade sarcoma with subsequent poorer outcome. MLS most commonly arises in the lower extremities, has a predilection for extra-pulmonary sites of metastatic disease, and is recognized to be radiosensitive. The purpose of the current article is to review the role of MRI in the management of MLS, including the characteristic features of the primary tumour, features which help to identify a round cell component and thus determine prognosis, the role of whole-body MRI for evaluation of extra-pulmonary metastatic disease, and the utility of MRI for assessing treatment response. The MRI differential diagnosis of MLS is also considered.
黏液样脂肪肉瘤（MLS）约占所有脂肪肉瘤的 30%。大多数为中等级别肿瘤，但如果存在 >5% 的圆形细胞成分，则认为其为高级别肉瘤，预后较差。MLS 最常发生于下肢，易发生肺外部位转移，且对放疗敏感。本文的目的是综述 MRI 在 MLS 管理中的作用，包括原发肿瘤的特征性表现、有助于识别圆形细胞成分并因此确定预后的特征、全身 MRI 评估肺外转移疾病的作用以及 MRI 评估治疗反应的效用。还考虑了 MLS 的 MRI 鉴别诊断。
