Hua Jianjun, Yang Wenting, Li Angcheng, Wang Sisis, Ying Mingliang
Department of Radiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, PR China.
Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, PR China.
Acta Radiol. 2025 Sep;66(9):999-1007. doi: 10.1177/02841851251337861. Epub 2025 May 21.
BackgroundMyxoid liposarcoma (MLS) is a subtype of liposarcoma characterized by its myxoid stroma and adipocyte differentiation. MLS is prone to recurrence and metastasis. Magnetic resonance imaging (MRI) plays a crucial role in evaluating tumor characteristics, enabling accurate diagnosis, and predicting patient prognosis.PurposeTo analyze the components of MLS by MRI features and assess their correlation with prognosis.Material and MethodsA total of 20 patients with MLS who underwent MRI were retrospectively included. Tumor components were analyzed by MRI features, and their prognostic correlation was assessed. Patients were divided into good and poor prognosis groups based on postoperative follow-up.ResultsThe proportions of non-fatty/non-myxoid components in the good and poor prognosis groups were 15.00% (range = 10.00%-20.00%) and 70.00% (range = 52.50%-77.50%), respectively ( < 0.001). The proportion of myxoid composition also differed significantly between the two groups (75.00%, [range = 65.00%-85.00%] vs. 25.00% [range = 17.50%-42.50%]; < 0.001). The good prognosis group had a greater mean apparent diffusion coefficient (ADC) value (1.66 ± 0.23 × 10 mm/s) and a lower mean ADC low signal ratio (5.00% [range = 0%-10.00%]) in the non-fatty/non-myxoid areas than the poor group (1.21 ± 0.41 × 10 mm/s; 20.00% [range = 11.00%-39.00%]; 0.006 and 0.001). The differences in the percentages of patients with a component ratio <25% and >50% in both the non-fatty/non-myxoid and myxoid groups were significant ( < 0.001 and 0.005).ConclusionImaging features were closely associated with the histological components of MLS. The use of MRI features for assessing MLS components has important implications for prognostic prediction.
背景
黏液样脂肪肉瘤（MLS）是脂肪肉瘤的一种亚型，其特征为黏液样基质和脂肪细胞分化。MLS易于复发和转移。磁共振成像（MRI）在评估肿瘤特征、实现准确诊断及预测患者预后方面发挥着关键作用。
目的
通过MRI特征分析MLS的成分，并评估其与预后的相关性。
材料与方法
回顾性纳入20例行MRI检查的MLS患者。通过MRI特征分析肿瘤成分，并评估其与预后的相关性。根据术后随访情况将患者分为预后良好组和预后不良组。
结果
预后良好组和预后不良组中非脂肪/非黏液样成分的比例分别为15.00%（范围=10.00%-20.00%）和70.00%（范围=52.50%-77.50%）（<0.001）。两组间黏液样成分的比例也存在显著差异（75.00%，[范围=65.00%-85.00%] 对25.00% [范围=17.50%-42.50%]；<0.001）。预后良好组在非脂肪/非黏液样区域的平均表观扩散系数（ADC）值更高（1.66±0.23×10 mm/s），非脂肪/非黏液样区域的平均ADC低信号比更低（5.00% [范围=0%-10.00%]），而预后不良组分别为1.21±0.41×10 mm/s；20.00% [范围=11.00%-39.00%]；<0.006和<0.001）。非脂肪/非黏液样组和黏液样组中成分比例<25%和>50%的患者百分比差异均有统计学意义（<0.001和<0.005）。
结论
影像学特征与MLS的组织学成分密切相关。利用MRI特征评估MLS成分对预后预测具有重要意义。
