人体内源性天然产物。
Human Endogenous Natural Products.
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 282 Chengfu Road, Haidian District, Beijing, China.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering and Peking-Tsinghua Center for Life Science, Peking University, 282 Chengfu Road, Haidian District, Beijing, China.
出版信息
Prog Chem Org Nat Prod. 2021;114:313-337. doi: 10.1007/978-3-030-59444-2_4.
Natural products are a class of chemical compounds that are biosynthesized by living organisms, including humans. Endogenous natural products are produced by human cells as well as by the human microbiome. This contribution describes the current understanding and recent progress made on endogenous natural products that are produced by human cells, including amines, steroids, and fatty acid-derived natural products. The co-metabolism and natural product produced by the human microbiome will also be described, including the involvement of tryptophan, bile acids, choline, and cysteine. New strategies and technologies have been introduced that can be applied to identify and characterize those natural products produced by the human microbiome in terms of their composition and physiological function.
天然产物是一类由生物体（包括人类）生物合成的化合物。内源性天然产物是由人类细胞和人类微生物组产生的。本贡献描述了目前对人类细胞产生的内源性天然产物的理解和最新进展，包括胺类、类固醇和脂肪酸衍生的天然产物。还将描述微生物组的共代谢和天然产物，包括色氨酸、胆汁酸、胆碱和半胱氨酸的参与。已经引入了新的策略和技术，可以应用于鉴定和表征微生物组产生的天然产物，包括其组成和生理功能。
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