Global Centre for Environmental Remediation, College of Engineering, Science and Environment, University of Newcastle, Callaghan, New South Wales, Australia.
Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, University of Newcastle, Callaghan, New South Wales, Australia.
Environ Toxicol Chem. 2021 Jul;40(7):1973-1982. doi: 10.1002/etc.5055. Epub 2021 May 25.
Perfluorobutane sulfonate (PFBS), due to its increasing use as an alternative to perfluooctane sulfonate (PFOS), is widely detected in humans and the environment, necessitating the evaluation of its potential ecotoxicological risk. We assessed the toxicity and bioaccumulation potential of PFBS in Caenorhabditis elegans, using lethality, locomotion, reproduction, life span, growth, and chemotactic behavior as the effect parameters. In addition, a total of 6 generations of exposed parent animals were monitored for locomotion, brood, and life span behaviors. Life span and brood size were significantly reduced in parent nematodes (P0) following exposure to ≥0.1 mM PFBS, but these negative effects did not transfer to the progeny. Although there was no remarkable effect on reproduction and life span in parent worms exposed to ≤0.01 mM PFBS, multigenerational exposure at 0.0005 mM significantly affected the F4 and F5 progeny. Furthermore, 0.01 to 2.0 mM of PFBS substantially retarded the locomotion behavior of P0 worms. At higher concentrations such as 1.0 mM, this negative effect on locomotion was transferred to the next generation (F1) but later recovered from F2 progeny onward. Our findings demonstrate for the first time that chronic exposure to PFBS at higher concentrations can cause behavioral toxicity and could be transferred to the progeny. These findings have significant implications for the environmental risk assessment of PFBS. Environ Toxicol Chem 2021;40:1973-1982. © 2021 SETAC.
全氟丁烷磺酸（PFBS）由于其作为全氟辛烷磺酸（PFOS）替代品的广泛使用，在人类和环境中广泛存在，因此需要评估其潜在的生态毒性风险。我们使用致死率、运动能力、繁殖、寿命、生长和趋化行为作为效应参数，评估了 PFBS 在秀丽隐杆线虫中的毒性和生物累积潜力。此外，还监测了 6 代暴露于母体动物的运动能力、幼体数量和寿命行为。暴露于≥0.1 mM PFBS 的亲代线虫的寿命和幼体数量显著减少（P0），但这些负面影响并未传递给后代。虽然暴露于≤0.01 mM PFBS 的亲代线虫的繁殖和寿命没有显著影响，但在 0.0005 mM 下的多代暴露显著影响了 F4 和 F5 代的后代。此外，0.01 至 2.0 mM 的 PFBS 大大延缓了 P0 线虫的运动行为。在更高的浓度（如 1.0 mM）下，这种对运动的负面影响会传递到下一代（F1），但从 F2 代开始恢复。我们的研究结果首次表明，慢性暴露于较高浓度的 PFBS 会导致行为毒性，并可能传递给后代。这些发现对 PFBS 的环境风险评估具有重要意义。Environ Toxicol Chem 2021;40:1973-1982。© 2021 SETAC。
