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将高阶强迫与修饰维度作为 DSM-5 强迫及相关障碍的治疗靶点。

Higher order compulsivity versus grooming dimensions as treatment targets for the DSM-5 obsessive-compulsive and related disorders.

机构信息

Center for OCD and Related Disorders (CORD), Massachusetts General Hospital, Boston, Massachusetts, USA.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Depress Anxiety. 2022 Jan;39(1):49-55. doi: 10.1002/da.23156. Epub 2021 Apr 1.

DOI:10.1002/da.23156
PMID:33793029
Abstract

BACKGROUND

Transdiagnostic definitions of obsessive-compulsive and related disorders (OCRDs) may represent useful treatment targets. The current study sought to characterize higher order dimensions underpinning the OCRDs in the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition, and examine their course during treatment.

METHODS

Adult patients (N = 407) completed measures of OCRDs, depression, and worry before and after intensive/residential treatment for OCRDs. Structural equation modeling was used to examine the comorbidity structure and temporal course of the symptoms.

RESULTS

Covariation of the symptoms was best represented by three dimensions: distress (depression and worry), compulsivity (obsessive-compulsive disorder, hoarding, and body dysmorphia), and grooming (hair pulling and skin picking). Latent change score modeling revealed significant reduction in the means of all three dimensions across treatment (Cohen's ds = -1.04, -0.62, and -0.23 for distress, compulsivity, and grooming, respectively). There was a strong correlation between change in compulsivity and grooming (r = .67) and change in compulsivity and distress (r = .80), but a small correlation between change in grooming and distress (r = .35).

CONCLUSIONS

The results indicate that OCRDs are underpinned by higher order compulsivity and grooming dimensions that differ in their association with distress. The results further suggest that the two dimensions may reflect promising intervention targets suitable for transdiagnostic treatment protocols.

摘要

背景

跨诊断的强迫及相关障碍(OCRD)定义可能代表了有用的治疗靶点。本研究旨在描述《精神障碍诊断与统计手册》第五版(DSM-5)中 OCRD 的高阶维度,并考察其在治疗过程中的变化。

方法

407 名成年患者在接受 OCRD 的强化/住院治疗前后,完成了 OCRD、抑郁和担忧的测量。结构方程模型被用于检验症状的共病结构和时间变化。

结果

症状的协变最好由三个维度来表示:苦恼(抑郁和担忧)、强迫性(强迫症、囤积症和体象障碍)和修饰(拔毛癖和皮肤搔抓癖)。潜在变化分数模型显示,所有三个维度在治疗过程中都有显著的均值降低(苦恼、强迫性和修饰的 Cohen's d 分别为-1.04、-0.62 和-0.23)。强迫性和修饰之间的变化(r=0.67)以及强迫性和苦恼之间的变化(r=0.80)有很强的相关性,但修饰和苦恼之间的变化(r=0.35)有很小的相关性。

结论

结果表明,OCRD 由高阶的强迫性和修饰维度来支撑,它们与苦恼的关联不同。结果进一步表明,这两个维度可能反映了有前途的干预靶点,适合于跨诊断治疗方案。

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