Department of Ophthalmology, Royal Victoria Hospital, Belfast, UK.
Centre for Public Health, Queen's University Belfast, Belfast, UK.
Ocul Immunol Inflamm. 2022 Aug;30(6):1511-1514. doi: 10.1080/09273948.2021.1880603. Epub 2021 Apr 1.
Unilateral Acute Idiopathic Maculopathy (UAIM) is a rare inflammatory macular condition affecting young adults with poorly understood etiology. This case report addresses this by suggesting potential etiology.
A retrospective review of patient records was carried out to obtain data for case report.
A 29-year-old male developed sudden visual loss in the left eye 1 day following the development of a sore throat. Optical Coherence Tomography (OCT) and fundal exam demonstrated subretinal/intraretinal fluid and disruption of the outer retina in keeping with UAIM. Serological testing revealed a raised Anti-Streptolysin O Titer and anti-DNAse-B antibody.
To date, UAIM has been known to be associated with a flu-like illness and a connection between coxsackievirus has been suggested but it has not been linked to streptococcal pharyngitis. We suggest a potential link between UAIM and streptococcal infection and that UAIM may be on the spectrum of post-streptococcal autoimmune disease.
单侧急性特发性黄斑病变（UAIM）是一种罕见的影响年轻人的炎症性黄斑疾病，其病因尚不清楚。本病例报告通过提示潜在病因对此进行了探讨。
对患者的病历进行回顾性研究，以获取病例报告的数据。
一名 29 岁男性在出现咽痛 1 天后左眼突发视力丧失。光学相干断层扫描（OCT）和眼底检查显示存在视网膜下/视网膜内液，外层视网膜中断，符合 UAIM 的表现。血清学检测显示抗链球菌溶血素 O 滴度升高和抗 DNAse-B 抗体阳性。
迄今为止，UAIM 已知与流感样疾病相关，已经有人提出柯萨奇病毒与之相关，但尚未与链球菌性咽炎相关联。我们提出 UAIM 与链球菌感染之间存在潜在联系，UAIM 可能是链球菌后自身免疫性疾病谱的一部分。
