UTP- Universidade Tuiuti do Paraná, Curitiba, Paraná, Brazil.
IFPR - Instituto Federal do Paraná, Curitiba, Paraná, Brazil.
PLoS One. 2021 Apr 1;16(4):e0249095. doi: 10.1371/journal.pone.0249095. eCollection 2021.
Neurodegenerative diseases are sporadic hereditary conditions characterized by progressive dysfunction of the nervous system. Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic paraplegia is a heterogeneous group of hereditary degenerative diseases involving the disorder of a single gene and is characterized by the progressive retrograde degeneration of fibers in the spinal cord.
To determine the benefits of vestibular rehabilitation involving virtual reality by comparing pre intervention and post intervention assessments in individuals with hereditary spastic paraplegia.
In this randomized controlled clinical trial from the Rebec platform RBR-3jmx67 in which allocation concealment was performed and the evaluators be blinded will be included. The participants will include 40 patients diagnosed with hereditary spastic paraplegia. The interventions will include vestibular rehabilitation with virtual reality using the Wii® console, Wii-Remote and Wii Balance Board (Nintendo), and the studies will include pre- and post intervention assessments. Group I will include twenty volunteers who performed balance games. Group II will include twenty volunteers who performed balance games and muscle strength games. The games lasted from 30 minutes to an hour, and the sessions were performed twice a week for 10 weeks (total: 20 sessions).
This study provides a definitive assessment of the effectiveness of a virtual reality vestibular rehabilitation program in halting the progression of hereditary spastic paraplegia, and this treatment can be personalized and affordable.
The study will determine whether a vestibular rehabilitation program with the Nintendo Wii® involving virtual reality can reduce the progressive effect of hereditary spastic paraplegia and serve as an alternative treatment option that is accessible and inexpensive. Rebec platform trial: RBR-3JMX67.
神经退行性疾病是一种散发性遗传性疾病，其特征是神经系统的进行性功能障碍。在这些症状中，前庭病是引起不适和生活质量下降的原因之一。遗传性痉挛性截瘫是一组异质性遗传性退行性疾病，涉及单个基因的紊乱，其特征是脊髓纤维进行性逆行变性。
通过比较遗传性痉挛性截瘫患者干预前后的评估，确定虚拟现实前庭康复的益处。
在 Rebec 平台 RBR-3jmx67 上进行这项随机对照临床试验，该平台采用了分配隐藏，并对评估者进行了盲法处理，将纳入 40 名遗传性痉挛性截瘫患者。干预措施包括使用 Wii®控制台、Wii-Remote 和 Wii 平衡板（任天堂）进行虚拟现实前庭康复，研究将包括干预前后的评估。第 1 组将包括 20 名进行平衡游戏的志愿者。第 2 组将包括 20 名进行平衡和肌肉力量游戏的志愿者。游戏时长为 30 分钟至 1 小时，每周进行两次，共进行 10 周（共 20 次）。
本研究对虚拟现实前庭康复方案在阻止遗传性痉挛性截瘫进展方面的有效性进行了明确评估，该治疗方案可个性化且负担得起。
该研究将确定任天堂 Wii®虚拟现实前庭康复方案是否可以减少遗传性痉挛性截瘫的进行性影响，并作为一种可及且负担得起的替代治疗选择。Rebec 平台试验：RBR-3JMX67。
