Laboratoire de Biogenèse Membranaire (LBM), Unité Mixte de Recherche UMR 5200, CNRS, Université de Bordeaux, Villenave d'Ornon, France.
ZMBP, Universität Tübingen, Auf der Morgenstelle 32 72076 Tübingen, Germany.
Plant Physiol. 2021 Apr 2;185(3):632-649. doi: 10.1093/plphys/kiaa063.
REMORINs (REMs) are a plant-specific protein family, proposed regulators of membrane-associated molecular assemblies and well-established markers of plasma membrane nanodomains. REMs play a diverse set of functions in plant interactions with pathogens and symbionts, responses to abiotic stresses, hormone signaling and cell-to-cell communication. In this review, we highlight the established and more putative roles of REMs throughout the literature. We discuss the physiological functions of REMs, the mechanisms underlying their nanodomain-organization and their putative role as regulators of nanodomain-associated molecular assemblies. Furthermore, we discuss how REM phosphorylation may regulate their functional versatility. Overall, through data-mining and comparative analysis of the literature, we suggest how to further study the molecular mechanisms underpinning the functions of REMs.
REMs（REMORINs）是一类植物特异性蛋白家族，被认为是膜相关分子组装的调节剂，也是质膜纳米域的公认标志物。在植物与病原体和共生体相互作用、对非生物胁迫的反应、激素信号转导和细胞间通讯等方面，REMs 发挥了多样化的功能。在这篇综述中，我们重点介绍了文献中已经确定和更多推测的 REMs 的作用。我们讨论了 REMs 的生理功能、其纳米域组织的潜在机制以及它们作为纳米域相关分子组装调节剂的潜在作用。此外，我们还讨论了 REM 磷酸化如何调节它们的多功能性。总的来说，通过对文献进行数据挖掘和比较分析，我们提出了如何进一步研究 REM 功能的分子机制。
