Moroni F, Russi P, Lombardi G, Beni M, Carlà V
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
J Neurochem. 1988 Jul;51(1):177-80. doi: 10.1111/j.1471-4159.1988.tb04852.x.
Kynurenic acid, a tryptophan metabolite able to antagonize the actions of the excitatory amino acids, has been identified and measured for the first time in the brain of mice, rats, guinea pigs, and humans by using an HPLC method. Its content was 5.8 +/- 0.9 in mouse brain, 17.8 +/- 2.0 in rat brain, 16.2 +/- 1.5 in guinea pig brain, 26.8 +/- 2.9 in rabbit brain, and 150 +/- 30 in human cortex (pmol/g wet wt. mean +/- SE). The regional distribution of this molecule was uneven. In rats, guinea pigs, and rabbits, the brainstem was the area richest in this compound. Tryptophan administration (100-300 mg/kg, i.p.) to rats resulted in a significant increase of the brain content of kynurenic acid. Similarly, 1 h after probenecid administration (200 mg/kg, i.p.), the brain content of kynurenate increased by fourfold, thus suggesting that its turnover rate is relatively fast.
犬尿喹啉酸是一种能够拮抗兴奋性氨基酸作用的色氨酸代谢产物，通过高效液相色谱法首次在小鼠、大鼠、豚鼠和人类的大脑中被鉴定和测量。其含量在小鼠脑中为5.8±0.9，大鼠脑中为17.8±2.0，豚鼠脑中为16.2±1.5，兔脑中为26.8±2.9，人类皮层中为150±30（皮摩尔/克湿重，平均值±标准误）。该分子的区域分布不均匀。在大鼠、豚鼠和兔中，脑干是该化合物含量最丰富的区域。给大鼠腹腔注射色氨酸（100 - 300毫克/千克）会导致犬尿喹啉酸的脑含量显著增加。同样，在给大鼠腹腔注射丙磺舒（200毫克/千克）1小时后，犬尿酸的脑含量增加了四倍，这表明其周转率相对较快。
