Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Department of Dermatology and Venereology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
J Cosmet Dermatol. 2022 Feb;21(2):461-472. doi: 10.1111/jocd.14110. Epub 2021 Apr 16.
Melasma is an acquired disorder of hyperpigmentation, affecting a million individuals worldwide. Energy-based devices (EBDs) employed to treat melasma include various types of lasers, intense pulsed light (IPL), and radiofrequency (RF). Recent studies have attempted to address recalcitrant and recurring melasma by combining energy-based devices with topical or oral medications.
This article reviews EBDs-based augmented treatment for melasma and suggests practical pathogenesis-oriented treatment regimens. Treatment algorithms are proposed to address various components of melasma.
A systematic PubMed search was conducted acquiring information from various studies on combination treatments of melasma involving EBDs.
The 286 retrieved articles were filtered by title to contain at least one type of energy-based modality such as laser, IPL, or RF along with at least one other treatment method. Based on their subject matter, combinations were further categorized into the subheadings: laser plus medication, laser plus laser, and IPL- and RF-containing treatment methods.
There are many energy-based combination treatments that have been explored for mitigation of melasma including laser therapy with medication, multi-laser therapies, IPL, RF, and microneedling devices. Melasma is an exceedingly difficult condition to treat, however, choosing the appropriate tailor-made treatment combination can improve the final outcome.
黄褐斑是一种获得性色素沉着障碍，影响着全球百万计的人群。用于治疗黄褐斑的能量设备包括各种类型的激光、强脉冲光（IPL）和射频（RF）。最近的研究试图通过将能量设备与局部或口服药物联合使用来解决难治性和复发性黄褐斑。
本文综述了基于能量设备的黄褐斑增强治疗，并提出了实用的基于发病机制的治疗方案。针对黄褐斑的各个组成部分提出了治疗方案。
通过系统的 PubMed 搜索，获取了涉及能量设备联合治疗黄褐斑的各种研究的信息。
从 286 篇检索到的文章中，通过标题筛选出至少一种能量模式，如激光、强脉冲光或射频，以及至少一种其他治疗方法。根据其主题，组合进一步分为以下小标题：激光加药物、激光加激光以及包含 IPL 和 RF 的治疗方法。
有许多基于能量的联合治疗方法已经被探索用于减轻黄褐斑，包括激光联合药物治疗、多种激光治疗、强脉冲光、射频和微针治疗设备。然而，黄褐斑是一种非常难以治疗的疾病，选择合适的个性化治疗组合可以改善最终的治疗效果。
