产超广谱β-内酰胺酶肠杆菌科的相对粪便丰度及其对重症监护病房患者感染的影响：一项初步研究。
Relative faecal abundance of extended-spectrum β-lactamase-producing Enterobacterales and its impact on infections among intensive care unit patients: a pilot study.
机构信息
Équipe mobile de microbiologie clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France; Service de maladies infectieuses et tropicales, Hôpital Necker - Enfants Malades, Paris, France; Institut Micalis UMR 1319, Université Paris - Saclay, INRAe, AgroParisTech, Châtenay Malabry, France.
Institut Micalis UMR 1319, Université Paris - Saclay, INRAe, AgroParisTech, Châtenay Malabry, France; Service de microbiologie clinique et plateforme de dosage des anti-infectieux, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
出版信息
J Hosp Infect. 2021 Jun;112:92-95. doi: 10.1016/j.jhin.2021.03.022. Epub 2021 Mar 29.
This pilot prospective study assessed the association between the faecal relative abundance of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) and the occurrence of ESBL-PE related infections. Twenty-four patients were included. The median ESBL relative abundance was 32.4%. The mean ESBL-PE relative abundance (ESBL-PE-RA) was more than five-fold higher in patients exposed during the last three months to antibiotics (P = 0.002). Furthermore, the mean ESBL relative abundance was more than two-fold higher in patients colonized with non-E. coli strains (P = 0.044). The mean ESBL-PE-RA was more than 10-fold higher for the concordant patients than for the discordant patients (59.1% vs 4.9%; P < 0.001).
本前瞻性研究旨在评估产extended-spectrum β-lactamase 的肠杆菌科细菌（ESBL-PE）粪便相对丰度与 ESBL-PE 相关感染发生的相关性。共纳入 24 名患者。ESBL 的中位数相对丰度为 32.4%。在过去三个月内接触过抗生素的患者的平均 ESBL-PE 相对丰度（ESBL-PE-RA）高出五倍以上（P=0.002）。此外，定植非大肠埃希菌菌株的患者的平均 ESBL 相对丰度高出两倍以上（P=0.044）。与不一致的患者相比，一致的患者的平均 ESBL-PE-RA 高出 10 倍以上（59.1% vs 4.9%；P<0.001）。
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