Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, UKM Bangi, Selangor, Malaysia.
Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh.
J Nutr Biochem. 2021 Jul;93:108634. doi: 10.1016/j.jnutbio.2021.108634. Epub 2021 Mar 29.
The high failure rate of the reductionist approach to discover effective and safe drugs to treat chronic inflammatory diseases has led scientists to seek alternative ways. Recently, targeting cell signaling pathways has been utilized as an innovative approach to discover drug leads from natural products. Cell signaling mechanisms have been identified playing key role in diverse diseases by inducing proliferation, cell survival and apoptosis. Phytochemicals are known to be able to modulate the cellular and molecular networks which are associated to chronic diseases including cancer-associated inflammation. In this review, the roles of dietary polyphenols (apigenin, kaempferol, quercetin, curcumin, genistein, isoliquiritigenin, resveratrol and gallic acid) in modulating multiple inflammation-associated cell signaling networks are deliberated. Scientific databases on suppressive effects of the polyphenols on chronic inflammation via modulation of the pathways especially in the recent five years are gathered and critically analyzed. The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa β, mitogen activated protein kinases, Wnt/β-catenin and phosphatidylinositol 3-kinase and protein kinase B via selective actions on various components of the networks. The suppressive effects of the polyphenols on the multiple cell signaling pathways reveal their potential use in prevention and treatment of chronic inflammatory disorders. Understanding the mechanistic effects involved in modulation of the signaling pathways by the polyphenols is necessary for lead identification and development of future functional foods for prevention and treatment of chronic inflammatory diseases.
还原论方法在发现治疗慢性炎症性疾病的有效和安全药物方面的高失败率，促使科学家寻求替代方法。最近，靶向细胞信号通路已被用作从天然产物中发现药物先导物的创新方法。细胞信号机制已被确定在多种疾病中发挥关键作用，包括诱导增殖、细胞存活和细胞凋亡。植物化学物质被认为能够调节与慢性疾病（包括与癌症相关的炎症）相关的细胞和分子网络。在这篇综述中，讨论了膳食多酚（芹菜素、山奈酚、槲皮素、姜黄素、染料木黄酮、甘草素、白藜芦醇和没食子酸）在调节多种与炎症相关的细胞信号网络中的作用。收集了关于多酚通过调节这些途径（特别是在最近五年）对慢性炎症的抑制作用的科学数据库，并进行了批判性分析。多酚能够通过选择性作用于网络的各种成分，调节几种与炎症相关的细胞信号通路，即核因子-κB、丝裂原激活蛋白激酶、Wnt/β-catenin 和磷脂酰肌醇 3-激酶和蛋白激酶 B。多酚对多种细胞信号通路的抑制作用表明它们具有预防和治疗慢性炎症性疾病的潜力。了解多酚调节信号通路所涉及的机制作用对于识别先导化合物和开发用于预防和治疗慢性炎症性疾病的未来功能性食品是必要的。
