Shah Muhammad Ajmal, Faheem Hafiza Ishmal, Hamid Ayesha, Yousaf Rimsha, Haris Muhammad, Saleem Uzma, Shah Ghulam Mujtaba, Alhasani Reem H, Althobaiti Norah A, Alsharif Ifat, Silva Ana Sanches
Department of Pharmacy, Hazara University, Mansehra, Pakistan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Med Res Rev. 2024 Jan;44(1):235-274. doi: 10.1002/med.21985. Epub 2023 Jul 24.
Aging, a fundamental physiological process influenced by innumerable biological and genetic pathways, is an important driving factor for several aging-associated disorders like diabetes mellitus, osteoporosis, cancer, and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. In the modern era, the several mechanisms associated with aging have been deeply studied. Treatment and therapeutics for age-related diseases have also made considerable advances; however, for the effective and long-lasting treatment, nutritional therapy particularly including dietary polyphenols from the natural origin are endorsed. These dietary polyphenols (e.g., apigenin, baicalin, curcumin, epigallocatechin gallate, kaempferol, quercetin, resveratrol, and theaflavin), and many other phytochemicals target certain molecular, genetic mechanisms. The most common pathways of age-associated diseases are mitogen-activated protein kinase, reactive oxygen species production, nuclear factor kappa light chain enhancer of activated B cells signaling pathways, metal chelation, c-Jun N-terminal kinase, and inflammation. Polyphenols slow down the course of aging and help in combatting age-linked disorders. This exemplified in the form of clinical trials on specific dietary polyphenols in various aging-associated diseases. With this context in mind, this review reveals the new insights to slow down the aging process, and consequently reduce some classic diseases associated with age such as aforementioned, and targeting age-associated diseases by the activities of dietary polyphenols of natural origin.
衰老作为一个受无数生物和遗传途径影响的基本生理过程，是糖尿病、骨质疏松症、癌症以及包括阿尔茨海默病和帕金森病在内的神经退行性疾病等几种与衰老相关疾病的重要驱动因素。在现代，与衰老相关的多种机制已得到深入研究。针对与年龄相关疾病的治疗方法也取得了长足进展；然而，为了实现有效且持久的治疗，营养疗法尤其是包括天然来源的膳食多酚受到认可。这些膳食多酚（如芹菜素、黄芩苷、姜黄素、表没食子儿茶素没食子酸酯、山奈酚、槲皮素、白藜芦醇和茶黄素）以及许多其他植物化学物质靶向特定的分子、遗传机制。与年龄相关疾病最常见的途径是丝裂原活化蛋白激酶、活性氧生成、活化B细胞核因子κB信号通路、金属螯合、c-Jun氨基末端激酶和炎症。多酚可减缓衰老进程，并有助于对抗与年龄相关的疾病。这在针对各种与衰老相关疾病的特定膳食多酚的临床试验中得到了体现。基于这一背景，本综述揭示了减缓衰老进程的新见解，从而减少一些上述与年龄相关的经典疾病，并通过天然来源膳食多酚的活性来靶向与年龄相关的疾病。
