Lexell J, Taylor C C, Sjöström M
Department of Anatomy, University of Umeå, Sweden.
J Neurol Sci. 1988 Apr;84(2-3):275-94. doi: 10.1016/0022-510x(88)90132-3.
In order to study the effects of increasing age on the human skeletal muscle, cross-sections (15 micron) of autopsied whole vastus lateralis muscle from 43 previously physically healthy men between 15 and 83 years of age were prepared and examined. The data obtained on muscle area, total number, size, proportion and distribution of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analysed using multivariate regression. The results show that the ageing atrophy of this muscle begins around 25 years of age and thereafter accelerates. This is caused mainly by a loss of fibers, with no predominant effect on any fiber type, and to a lesser extent by a reduction in fiber size, mostly of type 2 fibers. The results also suggest the occurrence of several other age-related adaptive mechanisms which could influence fiber sizes and fiber number, as well as enzyme histochemical fiber characteristics.
为了研究年龄增长对人体骨骼肌的影响，我们制备并检查了43名年龄在15至83岁之间、生前身体健康的男性尸检后的完整股外侧肌横切片（15微米）。使用多元回归分析了关于肌肉面积、1型（慢肌纤维）和2型（快肌纤维）纤维的总数、大小、比例及分布的数据。结果表明，该肌肉的衰老性萎缩始于25岁左右，此后加速。这主要是由纤维丧失引起的，对任何一种纤维类型都没有显著影响，在较小程度上是由纤维大小减小导致的，主要是2型纤维。结果还表明存在其他几种与年龄相关的适应性机制，这些机制可能会影响纤维大小、纤维数量以及酶组织化学纤维特征。
