抑肽酶对mdx小鼠的肌肉萎缩症没有明显的有益作用。

Chymostatin has no apparent beneficial effect on muscular dystrophy in the mdx mouse.

作者信息

Christie K N

机构信息

Department of Anatomy, The University, Dundee, Scotland, U.K.

出版信息

J Neurol Sci. 1988 Apr;84(2-3):341-6. doi: 10.1016/0022-510x(88)90138-4.

DOI:10.1016/0022-510x(88)90138-4

PMID:3379449

Abstract

The effect of the cathepsin B inhibitor chymostatin was studied in mice with an X chromosome-linked muscular dystrophy. Treatment for 7 weeks at a daily dose of 1 microgram/g body weight had no apparent beneficial effect: serum creatine kinase levels, histopathology and the activity of muscle cathepsin B were not significantly altered by the treatment.

摘要

在患有X染色体连锁型肌营养不良症的小鼠中研究了组织蛋白酶B抑制剂抑肽酶的作用。以每日1微克/克体重的剂量治疗7周没有明显的有益效果：治疗后血清肌酸激酶水平、组织病理学以及肌肉组织蛋白酶B的活性均未发生显著改变。