用蛋白酶抑制剂亮抑酶肽成功治疗小鼠肌肉萎缩症。
Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.
作者信息
Sher J H, Stracher A, Shafiq S A, Hardy-Stashin J
出版信息
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7742-4. doi: 10.1073/pnas.78.12.7742.
Abstract
Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.
摘要
对患有遗传性肌肉萎缩症的小鼠，在出现肌无力症状之前就开始进行腹腔注射蛋白酶抑制剂亮抑酶肽的治疗。与对照组相比，大量接受治疗的动物未出现肌肉萎缩的组织学证据。在该实验中，亮抑酶肽治疗预防（或延缓）了肌肉萎缩症的发作。
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