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[儿童局限性朗格汉斯细胞组织细胞增多症的临床特征]

[Clinical characteristics of localized Langerhans cell histiocytosis in children].

作者信息

Ming Cheng, Lou Fan, Lin Ken, Zeng Wenjuan, Sun Meihua, Gao Li, Wei Jingjuan, Ma Jing

机构信息

Department of Otolaryngology Head and Neck Surgery,Kunming Children's Hospital,Kunming,650228,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Mar;35(3):242-245. doi: 10.13201/j.issn.2096-7993.2021.03.011.

Abstract

To explore the clinical features of cephalic and facial limited langerhans cell histiocytosis (LCH) in children for improving its diagnosis and treatment. Clinical data of 8 children with cephalic and facial limited LCH were retrospectively analyzed, including the onset time of disease, lesion location, imaging data, clinical manifestations and treatment strategies. One case was preliminarily diagnosed as chronic inflammation with nasal back lesions, then conformed by repeated surgical pathology. Six cases were found to have simple cephalic and facial lumps without pain and swelling. One case was found to have temporal lump with suppurate in the lateral auditory canal. Five cases were treated with surgical excision of lesions. Three cases were treated with surgical excision of lesions, and continued with chemotherapy after confirmed pathological diagnosis. All cases were followed up for 2-3 years with good prognosis. Cephalic and facial limited LCH in children was easy to be misdiagnosed and should be regarded as animportant differential diagnosis of cephalic and facial lumps. Good outcome is achieved by treatment with surgical resection combined with adjuvant chemotherapy.

摘要

探讨儿童头面部局限性朗格汉斯细胞组织细胞增多症(LCH)的临床特点,以提高其诊断与治疗水平。回顾性分析8例儿童头面部局限性LCH的临床资料,包括发病时间、病变部位、影像学资料、临床表现及治疗策略。1例初诊为鼻背部病变慢性炎症,经多次手术病理确诊。6例表现为单纯头面部肿块,无疼痛及肿胀。1例表现为颞部肿块伴外耳道外侧化脓。5例行病变手术切除。3例行病变手术切除,病理确诊后继续化疗。所有病例随访2 - 3年,预后良好。儿童头面部局限性LCH易误诊,应作为头面部肿块的重要鉴别诊断。手术切除联合辅助化疗可取得良好疗效。

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本文引用的文献

1
[Analysis of clinical features of Craniofacial Langerhans cell histiocytosis in children].[儿童颅面部朗格汉斯细胞组织细胞增生症临床特征分析]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Nov;34(11):999-1001. doi: 10.13201/j.issn.2096-7993.2020.11.009.
2
Bone metabolism in Langerhans cell histiocytosis.朗格汉斯细胞组织细胞增多症中的骨代谢
Endocr Connect. 2018 Jul;7(7):R246-R253. doi: 10.1530/EC-18-0186. Epub 2018 Jul 2.

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