Xiao Lili, Liu Chengqi, Xia Liang, Feng Yanmei
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Apr;35(4):380-384. doi: 10.13201/j.issn.2096-7993.2021.04.022.
As isolated anatomical position, limited labyrinthine artery supply, and blood-labyrinth barrier hampers systemic drug delivery to the inner ear. The efficient concentration of drug treatment is unsatisfactory and there's possible side effects after systemic administration. Intratympanic injection of drug can bypass the blood-labyrinth and permeated to the hair cells or synaptic area via the round-or oval window of the cochlea. Efficacy and safety of pharmacotherapy has become increasingly relied on the inner ear delivery carrier system. The goal of this review focus on the anatomical barrier that need to be overcome in the intratympanic applications, the improvement of drug retention and specific targets, and the safety of novel drug carriers, these emerging strategies of local drug delivery promise novel and better guidance for the clinical application.
作为一个孤立的解剖位置，内耳迷路动脉供应有限以及血迷路屏障阻碍了全身药物向内耳的递送。药物治疗的有效浓度不尽人意，且全身给药后可能存在副作用。鼓室内注射药物可绕过血迷路屏障，并通过耳蜗的圆窗或卵圆窗渗透至毛细胞或突触区域。药物治疗的有效性和安全性越来越依赖于内耳递送载体系统。本综述的目标集中在鼓室内应用中需要克服的解剖学屏障、药物滞留和特定靶点的改善，以及新型药物载体的安全性，这些局部药物递送的新兴策略有望为临床应用提供新颖且更好的指导。
