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骨疗法在轻度肾上腺库欣综合征和库欣病中的应用。

Osteopathy in mild adrenal Cushing's syndrome and Cushing disease.

机构信息

Institute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan, Italy.

Dentistry Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

出版信息

Best Pract Res Clin Endocrinol Metab. 2021 Mar;35(2):101515. doi: 10.1016/j.beem.2021.101515. Epub 2021 Mar 10.

DOI:10.1016/j.beem.2021.101515
PMID:33795196
Abstract

Pathophysiology and effects of endogenous glucocorticoid (GC) excess on skeletal endpoints as well as awareness and management of bone fragility are reviewed. Cushing's syndrome (CS) increase the risk of fracture affecting prevalently bone quality. Bone antiresorptive agents (SERMs, bisphosphonates and denosumab) as well as teriparatide increase bone mineral density and in some instances reduce fracture risk. Awareness and management of bone health in CS can be improved.

摘要

本文回顾了内源性糖皮质激素（GC）过多对骨骼终点的病理生理学和影响，以及对骨脆弱性的认识和管理。库欣综合征（CS）增加了骨折风险，主要影响骨质量。骨抗吸收剂（SERMs、双磷酸盐和地舒单抗）以及特立帕肽可增加骨密度，并在某些情况下降低骨折风险。CS 患者的骨骼健康意识和管理可以得到改善。

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