Zdrojowy-Wełna Aleksandra, Stachowska Barbara, Bolanowski Marek
Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
Pituitary. 2024 Dec;27(6):837-846. doi: 10.1007/s11102-024-01427-7. Epub 2024 Jul 15.
Bone impairment associated with Cushing's disease (CD) is a complex disorder, mainly involving deterioration of bone quality and resulting in an increased fracture rate, often despite normal bone mineral density. Bone complications are common in patients with CD at the time of diagnosis but may persist even after successful treatment. There is currently no agreement on the optimal diagnostic methods, thresholds for anti-osteoporotic therapy and its timing in CD. In this review, we summarize the current data on the pathophysiology, diagnostic approach and management of bone complications in CD.
与库欣病（CD）相关的骨损害是一种复杂的病症，主要涉及骨质恶化并导致骨折率增加，即便骨矿物质密度正常时亦常如此。骨并发症在CD患者诊断时很常见，但即便在成功治疗后仍可能持续存在。目前对于CD的最佳诊断方法、抗骨质疏松治疗的阈值及其时机尚无共识。在本综述中，我们总结了关于CD骨并发症的病理生理学、诊断方法及管理的现有数据。
