动脉导管未闭闭合与坏死性小肠结肠炎发生的关联。
Association of closure of patent ductus arteriosus and development of necrotizing enterocolitis.
作者信息
Palder S B, Schwartz M Z, Tyson K R, Marr C C
机构信息
Department of Surgery, University of California, Davis, School of Medicine, Sacramento 95817.
出版信息
J Pediatr Surg. 1988 May;23(5):422-3. doi: 10.1016/s0022-3468(88)80439-1.
Over a 5-year period ending in June 1986, 234 neonates with evidence of a significant patent ductus arteriosus (PDA) underwent ductal manipulation. Thirty-four infants (15%) developed evidence of necrotizing enterocolitis (NEC). When NEC and treatment of PDA were within 72 hours of each other, there was a 71% mortality rate. When NEC and PDA ligation were greater than 72 hours apart, there were no deaths. Development of NEC prior to ductal closure was associated with a mortality of 57%, as opposed to no mortality when the development of NEC occurred after ductal closure. Our data suggest that infants who develop NEC before PDA ligation incur a high mortality.
在截至1986年6月的5年期间，234例有明显动脉导管未闭（PDA）证据的新生儿接受了导管操作。34例婴儿（15%）出现坏死性小肠结肠炎（NEC）迹象。当NEC与PDA治疗在彼此72小时内时，死亡率为71%。当NEC与PDA结扎间隔大于72小时时，则无死亡病例。导管闭合前发生NEC的死亡率为57%，而导管闭合后发生NEC则无死亡病例。我们的数据表明，在PDA结扎前发生NEC的婴儿死亡率很高。
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