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MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells.

作者信息

Zhang Heng, Chang Zhi, Qin Lu-Ning, Liang Bin, Han Jing-Xia, Qiao Kai-Liang, Yang Cheng, Liu Yan-Rong, Zhou Hong-Gang, Sun Tao

机构信息

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China.

Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China.

出版信息

Signal Transduct Target Ther. 2021 Apr 2;6(1):135. doi: 10.1038/s41392-021-00464-z.

DOI:10.1038/s41392-021-00464-z
PMID:33795651
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016859/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e8/8016859/a65c7e4dcf04/41392_2021_464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e8/8016859/a65c7e4dcf04/41392_2021_464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e8/8016859/a65c7e4dcf04/41392_2021_464_Fig1_HTML.jpg

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Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.缺氧诱导因子-1α（HIF-1α）和转移相关蛋白 2（MTA2）的相互作用环通过抑制 E-钙黏蛋白转录促进胰腺癌的进展。
J Pathol. 2018 Jul;245(3):349-360. doi: 10.1002/path.5089. Epub 2018 Jun 1.
3
Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.
心血管疾病中的酮体：以血管系统作为治疗靶点
JACC Basic Transl Sci. 2025 Jul 17;10(8):101328. doi: 10.1016/j.jacbts.2025.101328.
4
Post-translational acylation of proteins in cardiac hypertrophy.心脏肥大中蛋白质的翻译后酰化作用。
Nat Rev Cardiol. 2025 Apr 14. doi: 10.1038/s41569-025-01150-1.
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BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2.BDH1过表达通过抑制H3K9bhb介导的LCN2转录激活来减轻糖尿病性心肌病。
Cardiovasc Diabetol. 2025 Feb 28;24(1):101. doi: 10.1186/s12933-025-02646-3.
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Novel histone modifications and liver cancer: emerging frontiers in epigenetic regulation.新型组蛋白修饰与肝癌：表观遗传调控的新前沿
Clin Epigenetics. 2025 Feb 20;17(1):30. doi: 10.1186/s13148-025-01838-8.
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