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肢端肥大症的并发症和合并症-波兰中心的回顾性研究。

Complications and Comorbidities of Acromegaly-Retrospective Study in Polish Center.

机构信息

Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wrocław, Poland.

Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wrocław, Poland.

出版信息

Front Endocrinol (Lausanne). 2021 Mar 16;12:642131. doi: 10.3389/fendo.2021.642131. eCollection 2021.

Abstract

INTRODUCTION

In acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. Acromegaly comorbidities contribute to decreased life quality and premature mortality. The aim of our study was to assess the frequency of acromegaly complications and to evaluate diagnostic methods performed toward recognition of them.

MATERIALS AND METHODS

It was a retrospective study and we analyzed data of 179 patients hospitalized in the Department of Endocrinology, Diabetes and Isotope Therapy in Wroclaw Medical University (Poland) in 1976 to 2018 to create a database for statistical analysis.

RESULTS

The study group comprised of 119 women (66%) and 60 men (34%). The median age of acromegaly diagnosis was 50.5 years old for women (age range 20-78) and 46 for men (range 24-76). Metabolic disorders (hyperlipidemia, diabetes, and prediabetes) were the most frequently diagnosed complications in our study, followed by cardiovascular diseases and endocrine disorders (goiter, pituitary insufficiency, osteoporosis). BP measurement, ECG, lipid profile, fasting glucose or OGTT were performed the most often, while colonoscopy and echocardiogram were the least frequent.

CONCLUSIONS

In our population we observed female predominance. We revealed a decrease in the number of patients with active acromegaly and an increase in the number of well-controlled patients. More than 50% of patients demonstrated a coexistence of cardiac, metabolic and endocrine disturbances and only 5% of patients did not suffer from any disease from those main groups.

摘要

简介

在肢端肥大症中,慢性暴露于受损的 GH 和 IGF-I 水平会导致典型的肢端肥大症症状以及多种全身性并发症,如心血管、代谢、呼吸、内分泌和骨骼疾病。肢端肥大症的合并症会导致生活质量下降和过早死亡。我们研究的目的是评估肢端肥大症并发症的频率,并评估用于识别这些并发症的诊断方法。

材料和方法

这是一项回顾性研究,我们分析了 1976 年至 2018 年在弗罗茨瓦夫医科大学内分泌、糖尿病和同位素治疗科住院的 179 名患者的数据,以创建一个数据库进行统计分析。

结果

研究组包括 119 名女性(66%)和 60 名男性(34%)。女性肢端肥大症诊断的中位年龄为 50.5 岁(年龄范围为 20-78 岁),男性为 46 岁(年龄范围为 24-76 岁)。在我们的研究中,代谢紊乱(高血脂、糖尿病和前期糖尿病)是最常诊断的并发症,其次是心血管疾病和内分泌疾病(甲状腺肿、垂体功能减退、骨质疏松症)。我们最常进行血压测量、心电图、血脂谱、空腹血糖或 OGTT,而结肠镜检查和超声心动图则是最不常进行的检查。

结论

在我们的人群中,我们观察到女性占优势。我们发现活动肢端肥大症患者的数量减少,而控制良好的患者数量增加。超过 50%的患者表现出心脏、代谢和内分泌紊乱的共存,只有 5%的患者没有患任何主要疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bbb/8009182/cf34668118ab/fendo-12-642131-g001.jpg

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