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本文引用的文献

1
The temporal and causal relationship between inflammation and neurodegeneration in multiple sclerosis.多发性硬化症中炎症与神经退行性变的时间和因果关系。
Mult Scler. 2020 Jul;26(8):876-886. doi: 10.1177/1352458519886943. Epub 2019 Nov 4.
2
Clinical trials in multiple sclerosis: potential future trial designs.多发性硬化症的临床试验：未来可能的试验设计
Ther Adv Neurol Disord. 2019 May 13;12:1756286419847095. doi: 10.1177/1756286419847095. eCollection 2019.
3
Neurofilament light chain: An important step toward a disease biomarker in multiple sclerosis.神经丝轻链：迈向多发性硬化症疾病生物标志物的重要一步。
Neurology. 2019 Mar 5;92(10):451-452. doi: 10.1212/WNL.0000000000007022. Epub 2019 Feb 8.
4
Clinical features and prognosis of amyotrophic lateral sclerosis in Africa: the TROPALS study.非洲肌萎缩侧索硬化症的临床特征和预后：TROPALS 研究。
J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):20-29. doi: 10.1136/jnnp-2018-318469. Epub 2018 Sep 21.
5
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.奥瑞珠单抗与安慰剂治疗原发性进行性多发性硬化症。
N Engl J Med. 2017 Jan 19;376(3):209-220. doi: 10.1056/NEJMoa1606468. Epub 2016 Dec 21.
6
Defining the clinical course of multiple sclerosis: the 2013 revisions.多发性硬化症临床病程的定义：2013年修订版
Neurology. 2014 Jul 15;83(3):278-86. doi: 10.1212/WNL.0000000000000560. Epub 2014 May 28.
7
Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties.针对 CD20 的单克隆抗体的表位相互作用及其与功能特性的关系。
MAbs. 2013 Jan-Feb;5(1):22-33. doi: 10.4161/mabs.22771. Epub 2012 Dec 4.
8
Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial.利妥昔单抗治疗原发性进行性多发性硬化症患者：一项随机双盲安慰剂对照多中心试验的结果
Ann Neurol. 2009 Oct;66(4):460-71. doi: 10.1002/ana.21867.

Should ocrelizumab be used in non-active primary progressive multiple sclerosis? Time for a re-assessment.

作者信息

Manouchehri Navid, Stüve Olaf

机构信息

Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Neurology Section, VA North Texas Health Care System, Medical Service, 4500 South Lancaster Rd., Dallas, TX 75216, USA Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9036, USA.

出版信息

Ther Adv Neurol Disord. 2021 Feb 1;14:1756286421990500. doi: 10.1177/1756286421990500. eCollection 2021.

DOI:10.1177/1756286421990500
PMID:33796142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7970673/
Abstract
摘要