Kılınçer Abidin, Durmaz Mehmet Sedat, Kıraç Cem Onur, Baldane Süleyman, Ateş Fatih, Batur Abdüssamet
Department of Radiology, Selçuk University School of Medicine, Konya, Turkey.
Division of Endocrinology, Department of Internal Medicine, Selçuk University School of Medicine, Konya, Turkey.
J Ultrason. 2021;21(84):41-47. doi: 10.15557/JoU.2021.0006. Epub 2021 Mar 8.
To determine the parenchymal vascularity of the thyroid gland with color superb microvascular imaging in patients with Graves' disease, and compare the vascularization index values with healthy subjects.
The thyroid glands of 37 patients whose laboratory and clinical findings were consistent with Graves' disease, and 40 asymptomatic subjects with normal laboratory values, were examined using color superb microvascular imaging. Measurements of the vascularization index were performed with a free region of interest which was drawn along the outer margin of the gland on the color superb microvascular imaging mode. The vascularization index values obtained in the Graves' disease and control groups were compared. A correlation analysis was performed between the vascularization index values and laboratory and grayscale US parameters.
The median vascularization index value of the thyroid parenchyma in patients with Graves' disease was significantly higher than in the asymptomatic group [median (min-max); 12 (2.3-32.1) vs 5.04 (1.1-10.8), <0.001]. When the cutoff value of the vascularization index is determined as 6.3, Graves' disease can be diagnosed with 83.8% sensitivity and 70% specificity.
The vascularization index obtained with color superb microvascular imaging can be a quantitative indicator of parenchymal vascularity in the diagnosis of Graves' disease, and serve as a supportive tool.
运用彩色超微血管成像技术测定Graves病患者甲状腺实质血管情况，并将血管化指数值与健康受试者进行比较。
对37例实验室及临床检查结果符合Graves病的患者以及40例实验室检查值正常的无症状受试者的甲状腺，采用彩色超微血管成像技术进行检查。在彩色超微血管成像模式下，沿着甲状腺外缘绘制一个自由感兴趣区来测量血管化指数。比较Graves病组和对照组获得的血管化指数值。对血管化指数值与实验室检查值及灰度超声参数进行相关性分析。
Graves病患者甲状腺实质的血管化指数中位数显著高于无症状组[中位数（最小值 - 最大值）；12（2.3 - 32.1）对5.04（1.1 - 10.8），P < 0.001]。当将血管化指数的截断值确定为6.3时，诊断Graves病的灵敏度为83.8%，特异度为70%。
彩色超微血管成像获得的血管化指数可作为Graves病诊断中实质血管情况的定量指标，并作为一种辅助工具。
