Roberto Marcello, Pasqualone Gianmario, Di Donato Nicola G, Malik Zaheer, Bhaiyat Sheereen, Caponio Vito Ca, Lillo Giuseppe, Vallone Gianfranco, Rinaldi Ciro R, Martinelli Vincenzo
Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise Campobasso, Italy.
Obstetrics and Gynaecology Operating Unit, "Antonio Cardarelli" Hospital, Azienda Sanitaria Regionale del Molise (ASReM) Campobasso, Italy.
Am J Blood Res. 2021 Feb 15;11(1):84-92. eCollection 2021.
Foetal spleen is described as a transient focus of haematopoiesis between the 3 and 5 month of gestation: this function is however entirely replaced by the bone marrow before the end of pregnancy. This study identifies haematopoiesis in foetal spleen by exploring changes of echogenicity during its development throughout gestation. Two intervals of pregnancy were studied: Mid-Pregnancy (Mid-P, 19-23 weeks) and End-Pregnancy (End-P, 37-41 weeks). The foetal spleen was investigated in 80 pregnant women (41 vs 39). Due to quality criteria the comparison was made between 60 images (30 Mid-P vs 30 End-P). The acquisition of splenic parenchyma was followed by clustering segmentation. We identified two new parameters resulted from the clustering segmentation: Dark Ratio (DR) and Light Ratio (LR). These are related to splenic echogenicity expressing the percentage of dark and light signal in the clustered image, influenced by blood cellularity. The mean of DR value was different among the 2 groups (0.0631 vs 0.0483, ), while LR did not show any significant differences. We conclude that DR may represent a reliable radiomic parameter in the determination of extramedullary haematopoiesis in the spleen.
胎儿脾脏被描述为妊娠3至5个月期间造血的一个短暂部位：然而，在妊娠结束前，这项功能完全被骨髓所取代。本研究通过探索整个妊娠期胎儿脾脏发育过程中回声性的变化来确定其造血情况。研究了两个妊娠阶段：妊娠中期（Mid-P，19 - 23周）和妊娠末期（End-P，37 - 41周）。对80名孕妇（41名对39名）的胎儿脾脏进行了研究。由于质量标准，在60幅图像（30幅Mid-P对30幅End-P）之间进行了比较。对脾脏实质进行采集后进行聚类分割。我们从聚类分割中确定了两个新参数：暗比率（DR）和亮比率（LR）。这些与脾脏回声性相关，表达了聚类图像中暗信号和亮信号的百分比，受血细胞含量影响。两组之间DR值的均值不同（0.0631对0.0483），而LR没有显示出任何显著差异。我们得出结论，DR可能是确定脾脏髓外造血的一个可靠的影像组学参数。
