大鼠干扰素可增强培养的大鼠肌管中乙酰胆碱受体的表达。
Rat interferon enhances the expression of acetylcholine receptors in rat myotubes in culture.
作者信息
André P, Braun S, Passaquin A C, Coupin G, Bartholeyns J, Warter J M, Poindron P
机构信息
Departement d'Immunologie et d'Immunopharmacologie, Université Louis Pasteur, Strasbourg, France.
出版信息
J Neurosci Res. 1988 Mar;19(3):297-302. doi: 10.1002/jnr.490190304.
Interferon enhances alpha-bungarotoxin binding on 5-day-old rat myotubes. The increase is time- and dose-dependent. KD for alpha-bungarotoxin remains unchanged in the presence and in the absence of interferon, while the maximum number of binding sites is dramatically affected by interferon. Cycloheximide inhibits the effect of interferon, which suggests that the enhancement of alpha-bungarotoxin binding depends on protein synthesis.
干扰素可增强5日龄大鼠肌管上α-银环蛇毒素的结合。这种增加具有时间和剂量依赖性。在存在和不存在干扰素的情况下，α-银环蛇毒素的解离常数（KD）保持不变，而结合位点的最大数量受到干扰素的显著影响。放线菌酮可抑制干扰素的作用，这表明α-银环蛇毒素结合的增强依赖于蛋白质合成。
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