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融合前培养的成肌细胞中乙酰胆碱受体的出现。

Appearance of acetylcholine receptors in cultured myoblasts prior to fusion.

作者信息

Teng N N, Fiszman M Y

出版信息

J Supramol Struct. 1976;4(3):381-7. doi: 10.1002/jss.400040309.

DOI:10.1002/jss.400040309
PMID:772316
Abstract

The development of the acetylcholine receptors in chick embryo myoblasts from 11-day old embryos was studied in vitro. Using the purified alpha-bungarotoxin labeled with radioactive iodide, a high concentration of acetylcholine receptors was found in the prefusing myoblasts; most of these receptors were located in the interior of the myoblasts. However, upon the completion of myoblasts fusion, the majority of the acetylcholine receptors appeared on the external cell surface of the myotubes.

摘要

对来自11日龄鸡胚的成肌细胞中乙酰胆碱受体的发育进行了体外研究。使用用放射性碘标记的纯化α-银环蛇毒素,发现预融合成肌细胞中存在高浓度的乙酰胆碱受体;这些受体大多位于成肌细胞内部。然而,成肌细胞融合完成后,大多数乙酰胆碱受体出现在肌管的细胞外表面。

相似文献

1
Appearance of acetylcholine receptors in cultured myoblasts prior to fusion.融合前培养的成肌细胞中乙酰胆碱受体的出现。
J Supramol Struct. 1976;4(3):381-7. doi: 10.1002/jss.400040309.
2
Rat interferon enhances the expression of acetylcholine receptors in rat myotubes in culture.大鼠干扰素可增强培养的大鼠肌管中乙酰胆碱受体的表达。
J Neurosci Res. 1988 Mar;19(3):297-302. doi: 10.1002/jnr.490190304.
3
A possible modulation of acetylcholine receptors of embryonic chick muscle cells by alpha-bungarotoxin.
J Supramol Struct. 1979;10(1):39-50. doi: 10.1002/jss.400100105.
4
Effect of fibroblast growth factor on the division and fusion of bovine myoblasts.成纤维细胞生长因子对牛成肌细胞分裂与融合的影响。
J Cell Biol. 1976 Aug;70(2 pt 1):395-405. doi: 10.1083/jcb.70.2.395.
5
Metabolism of acetylcholine receptors in skeletal muscle.骨骼肌中乙酰胆碱受体的代谢
Natl Cancer Inst Monogr. 1978 May(48):277-94.
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Microtubules and the formation of acetylcholine receptor clusters in chick embryonic muscle cells.微管与鸡胚肌肉细胞中乙酰胆碱受体簇的形成
Eur J Cell Biol. 1985 Nov;39(1):173-8.
7
[Expression of myogenic differentiation program in cultured normal postmitotic mononucleated myoblasts and the aberrant differentiation in rhabdomyosarcoma cells].[培养的正常有丝分裂后单核成肌细胞中肌源性分化程序的表达及横纹肌肉瘤细胞中的异常分化]
Shi Yan Sheng Wu Xue Bao. 1994 Mar;27(1):79-89.
8
Acetylcholine receptors of cultured muscle cells demonstrated with ferritin-alpha-bungarotoxin conjugates.用铁蛋白-α-银环蛇毒素偶联物显示培养肌细胞的乙酰胆碱受体。
J Cell Sci. 1974 Nov;16(2):473-9. doi: 10.1242/jcs.16.2.473.
9
Regulation of the number of alpha-bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist.1,4-二氢吡啶钙通道拮抗剂对培养的鸡肌管中α-银环蛇毒素结合位点数量的调节作用
J Neurosci Res. 1988 Mar;19(3):321-5. doi: 10.1002/jnr.490190307.
10
Newly synthesized acetylcholine receptors are located in the Golgi apparatus.新合成的乙酰胆碱受体位于高尔基体中。
J Cell Biol. 1978 Jan;76(1):237-44. doi: 10.1083/jcb.76.1.237.

引用本文的文献

1
Isolation and characterization of human muscle cells.人类肌肉细胞的分离与特性分析。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5623-7. doi: 10.1073/pnas.78.9.5623.
2
Induction of muscle genes in neural cells.神经细胞中肌肉基因的诱导。
J Cell Biol. 1984 Feb;98(2):427-35. doi: 10.1083/jcb.98.2.427.
3
Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick.烟碱型乙酰胆碱受体α亚基转录本在鸡肌肉生成和运动终板发育过程中的定位
J Cell Biol. 1989 Mar;108(3):1025-37. doi: 10.1083/jcb.108.3.1025.
4
Localization of acetylcholine receptors by means of horseradish peroxidase-alpha-bungarotoxin during formation and development of the neuromuscular junction in the chick embryo.在鸡胚神经肌肉接头形成和发育过程中,通过辣根过氧化物酶-α-银环蛇毒素对乙酰胆碱受体进行定位。
J Cell Biol. 1979 Jul;82(1):195-211. doi: 10.1083/jcb.82.1.195.