Japa Ingrid, Ancha Bhavya, Custodio Antonio, Ohrenschall Rachel, Cordero Ramona, Deverlis Adriana, Chapman Jennifer, Hickson Meredith R, Steenhoff Andrew P, Lowenthal Elizabeth D
Niños Primeros en Salud, Consuelo, Dominican Republic.
Universidad Central del Este, San Pedro de Macorís, Dominican Republic.
Glob Pediatr Health. 2021 Mar 19;8:2333794X211002949. doi: 10.1177/2333794X211002949. eCollection 2021.
. The World Health Organization recommends biannual deworming with single-dose albendazole for all children over 1 year in regions where soil-transmitted helminths (STH) are endemic. There are limited data from the Dominican Republic (DR) on the effectiveness of deworming programs. . Between January and June 2019, we enrolled 63 preschool-aged children at a community clinic in the DR. Participants received albendazole at enrollment. Stool samples were collected and examined for parasites at enrollment, 2 to 4 and 12 to 16 weeks post-albendazole. Caregivers were surveyed on home hygiene practices and children's symptoms. . At enrollment, 1 or more parasites were noted in 89% of samples. (68%) was the most common species, followed by (35%) and (8%). Two-to-four weeks post-albendazole, fewer than half of those with infections at baseline had cleared the infection. STH symptoms significantly improved between enrollment and 2 to 4 weeks. By 12 to 16 weeks after treatment, infections were as high as baseline. . Although limited by size and available technology, our study contributes data on STH in the DR. Single-dose deworming with albendazole did not reduce infections in our sample. As STH are the most common neglected tropical diseases and negatively impact children's health globally, further studies on both effective deworming programs and interventions to prevent STH are needed.
世界卫生组织建议，在土壤传播的蠕虫（STH）流行地区，对所有1岁以上儿童每半年使用单剂量阿苯达唑进行驱虫。关于多米尼加共和国（DR）驱虫项目有效性的数据有限。2019年1月至6月，我们在多米尼加共和国的一家社区诊所招募了63名学龄前儿童。参与者在入组时接受了阿苯达唑治疗。在入组时、服用阿苯达唑后2至4周以及12至16周采集粪便样本并检查寄生虫。对护理人员进行了家庭卫生习惯和儿童症状的调查。入组时，89%的样本中发现了1种或多种寄生虫。蛔虫（68%）是最常见的种类，其次是鞭虫（35%）和钩虫（8%）。服用阿苯达唑后2至4周，基线时感染蛔虫的人中不到一半清除了感染。在入组至2至4周期间，STH症状显著改善。到治疗后12至16周，蛔虫感染率与基线时一样高。尽管受到样本量和现有技术的限制，但我们的研究提供了多米尼加共和国STH的数据。单剂量阿苯达唑驱虫并未降低我们样本中的蛔虫感染率。由于STH是最常见的被忽视的热带病，对全球儿童健康产生负面影响，因此需要进一步研究有效的驱虫项目和预防STH的干预措施。
